<i>Helicobacter pylori</i> infection in physical examination population and its correlations with hypertension, glucose and lipid metabolism

GAO Yan; ZHANG Dan; LI Qian; ZHANG Junbo; LIU Liu; ZHU Ya'nan; GUO Shanshan

doi:10.7619/jcmp.20241938

Journal of Clinical Medicine in Practice > 2024 > 28(23): 100-104. > DOI: 10.7619/jcmp.20241938

GAO Yan, ZHANG Dan, LI Qian, ZHANG Junbo, LIU Liu, ZHU Ya'nan, GUO Shanshan. Helicobacter pylori infection in physical examination population and its correlations with hypertension, glucose and lipid metabolism[J]. Journal of Clinical Medicine in Practice, 2024, 28(23): 100-104. DOI: 10.7619/jcmp.20241938

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Helicobacter pylori infection in physical examination population and its correlations with hypertension, glucose and lipid metabolism

Department of General Practice, Rocket Force Characteristic Medical Center of Chinese People's Liberation Army, Beijing, 100088

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Received Date: May 10, 2024
Revised Date: October 08, 2024

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Abstract

Abstract

Objective
To investigate the infection of Helicobacter pylori (Hp) and its relationships with hypertension, glucose and lipid metabolism in the physical examination population.
Methods
A total of 287 individuals undergoing physical examinations were selected as study subjects. Based on the results of ¹⁴C-urea breath test screening for Hp infection, participants were divided into Hp-positive group (n=125) and Hp-negative group (n=162). Baseline characteristics and glycolipid metabolism levels were compared between the two groups. Multivariate Logistic regression analysis was used to identify factors influencing Hp infection in the study population.
Results
The Hp infection rate among the 287 individuals was 43.55%. The frequency of eating out in the Hp-positive group was 34.40%, which was significantly higher than 13.58% in the Hp-negative group (P < 0.05). Fasting blood glucose (FBG), insulin resistance index (HOMA-IR), total cholesterol (TC) and triacylglycerol (TG) in the HP-positive group were significantly higher, and high-density lipoprotein cholesterol (HDL-C) was significantly lower than that in the Hp-negative group (P < 0.05). Multivariate Logistic regression analysis revealed that eating out (OR=1.401, 95%CI, 1.142 to 1.717), FBG (OR=3.865, 95%CI, 1.810 to 8.253), TC (OR=4.141, 95%CI, 2.025 to 8.469), TG (OR= 4.259, 95%CI, 2.128 to 8.524) and HDL-C (OR=4.125, 95%CI, 1.989 to 8.552) were factors influencing Hp infection in the study population (P < 0.05). HOMA-IR was not associated with Hp infection in the study population (P>0.05).
Conclusion
The prevalence of Hp infection is high among individuals undergoing physical examinations, and Hp infection has significant association with abnormalities in glycolipid metabolism, but no association with hypertension.
- physical examination population,
- Helicobacter pylori infection,
- hypertension,
- glycolipid metabolism,
- total cholesterol

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