Association between symptom burden and depression after hepatectomy in hepatocellular carcinoma patients: a moderated mediation model

SONG Haixia; ZANG Li; WEN Yating

doi:10.7619/jcmp.20241536

Journal of Clinical Medicine in Practice > 2024 > 28(17): 68-72, 78. > DOI: 10.7619/jcmp.20241536

SONG Haixia, ZANG Li, WEN Yating. Association between symptom burden and depression after hepatectomy in hepatocellular carcinoma patients: a moderated mediation model[J]. Journal of Clinical Medicine in Practice, 2024, 28(17): 68-72, 78. DOI: 10.7619/jcmp.20241536

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Association between symptom burden and depression after hepatectomy in hepatocellular carcinoma patients: a moderated mediation model

Department of General Surgery, the Second Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, 710032

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Received Date: April 15, 2024
Revised Date: July 11, 2024

Graphical Abstract

Abstract

Abstract

Objective
To explore the mechanisms associated with symptom burden and depression in hepatocellular carcinoma patients after hepatectomy.
Methods
A total of 230 hospitalized patients with hepatocellular carcinoma who were underwent hepatectomy for the first time were selected as study subjects. A self-administered General Information Questionnaire, MD Anderson Symptom Inventory, Patient Health Questionnaire, Connor-Davidson Resilience Scale, and Pittsburgh Sleep Quality Index were used to investigate sociodemographic, sociodemographic data, symptom burden, depression, psychological resilience, and sleep quality of postoperative hepatocellular carcinoma patients. Pearson correlation analysis was used to identify specific associations among variables. The mediating and moderating effects of psychological resilience and sleep quality between symptom burden and depression were analyzed using the Process.
Results
Psychological resilience partially mediated the association between symptom burden and depression (β=-0.137, SE=0.084, 95%CI, -0.243 to -0.082), with the mediating effect accounting for 44.08% of the total effect, and the interaction term between symptom burden and sleep quality had predictive value for psychological resilience (β=-0.014, t=-6.209, P < 0.001).
Conclusion
Postoperative symptom burden in hepatocellular carcinoma patients can play a role in depression through psychological resilience, where the effect of symptom burden on psychological resilience is moderated by sleep quality. Clinical staff should take reducing patients'postoperative symptom burden and improving psychological elasticity with sleep quality as important goals and develop appropriate nursing interventions to reduce the risk of depression in patients.
- liver cancer,
- symptom burden,
- psychological resilience,
- sleep quality,
- depression

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References (19)

References

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Association between symptom burden and depression after hepatectomy in hepatocellular carcinoma patients: a moderated mediation model