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ZHU Guanghao, ZHU Minhui, ZHENG Hongliang. Research progress on the role of long non-coding RNA in regulating cancer radiosensitivity[J]. Journal of Clinical Medicine in Practice, 2024, 28(16): 142-148. DOI: 10.7619/jcmp.20240768
Citation: ZHU Guanghao, ZHU Minhui, ZHENG Hongliang. Research progress on the role of long non-coding RNA in regulating cancer radiosensitivity[J]. Journal of Clinical Medicine in Practice, 2024, 28(16): 142-148. DOI: 10.7619/jcmp.20240768
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Research progress on the role of long non-coding RNA in regulating cancer radiosensitivity

  • Department of Otolaryngology, Head and Neck Surgery, Shanghai Changhai Hospital of the First Affiliated Hospital of Naval Medical University of the Chinese People's Liberation Army, Shanghai, 200433

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  • Received Date: February 24, 2024
  • Revised Date: May 05, 2024
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    • Abstract

  • The regulatory role of long non-coding RNA (lncRNA) in cancer radiosensitivity has obtained increasing attention. Radiotherapy is one of the primary treatment methods for cancer, yet some patients experience disease progression or recurrence due to radioresistance. Exploring the regulatory mechanisms of radiosensitivity during cancer radiotherapy and identifying new molecular therapeutic targets are crucial for enhancing the efficacy of cancer radiotherapy. LncRNA can participate in the response of cancer to radiotherapy and regulate cancer radiosensitivity through various pathways, including modulation of the DNA damage response, apoptosis, cancer stem cells, and epithelial-mesenchymal transition (EMT). This study discussed the research progress on the mechanisms of lncRNA in the field of cancer radiotherapy, highlighting their important roles in enhancing tumor radiosensitivity.

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