| Citation: |
XU Zhijun, YANG Zhenbin, QIU Wei, XIA Wenjuan, CHEN Lili. Effect of Zuojin Jiawei Formula combined with acupuncture and moxibustion in treating gastroesophageal reflux disease of liver-stomach stagnation heat type and its impact on brain-gut peptides[J]. Journal of Clinical Medicine in Practice, 2024, 28(5): 63-67. DOI: 10.7619/jcmp.20233716
|
To investigate the therapeutic effect of Zuojin Jiawei Formula combined with acupuncture and moxibustion in gastroesophageal reflux disease (GERD) of liver-stomach stagnation heat type and its impact on brain-gut peptides.
A total of 160 patients with GERD of liver-stomach stagnation heat type who were diagnosed and treated at the outpatient department of spleen and stomach of Yangzhou Hospital of Traditional Chinese Medicine from July 2021 to December 2022 were randomly divided into four groups: western medicine group, traditional Chinese medicine group, acupuncture group, and traditional Chinese medicine combined with acupuncture group, with 40 patients in each group. The western medicine group was treated with rabeprazole as the main drug, the traditional Chinese medicine group was treated with Zuojin Jiawei Formula alone, the traditional Chinese medicine combined with acupuncture group was treated with acupuncture at Zusanli, Zhongwan, Taichong, and Neiguan on the basis of Zuojin Jiawei Formula, and the acupuncture group was treated with acupuncture at Zusanli, Zhongwan, Taichong, and Neiguan alone. All four groups were treated for 8 weeks, and the clinical efficacy along with Reflux Disease Questionnaire score, main symptoms score of traditional Chinese medicine, esophageal mucosa score, and vasoactive intestinal peptide level before and after treatment were compared among the four groups.
After treatment, the total effective rate of the traditional Chinese medicine combined with acupuncture group was higher than the other three groups, and the scores of main symptoms of traditional Chinese medicine, Reflux Disease Questionnaire score, esophageal mucosa score, and plasma vasoactive intestinal peptide levels were lower than the other three groups and before treatment(P < 0.05).
Zuojin Jiawei Formula combined with acupuncture can effectively alleviate the clinical symptoms of GERD, promote mucosal healing, and improve treatment outcomes.
| [1] |
陈利嫒, 王佳, 侯奕同. 胃食管反流病治疗的研究进展[J]. 国际消化病杂志, 2020, 40(4): 215-218. https://www.cnki.com.cn/Article/CJFDTOTAL-GWXH202004002.htm
|
| [2] |
中华中医药学会脾胃病分会. 胃食管反流病中医诊疗专家共识意见(2017)[J]. 中国中西医结合消化杂志. 2017, 25(5): 321-326. https://www.cnki.com.cn/Article/CJFDTOTAL-SHZZ201911003.htm
|
| [3] |
中华医学会消化病学分会. 2020年中国胃食管反流病专家共识[J]. 中华消化杂志, 2020, 40(10): 649-663. doi: 10.3760/cma.j.cn311367-20200918-00558
|
| [4] |
石瑞春, 杨志伟, 陈永贵, 等. 采用耐信量表临床诊断胃食反流病(GERD)的可行性探讨[J]. 医药前沿, 2012(35): 19-20. doi: 10.3969/j.issn.2095-1752.2012.35.016
|
| [5] |
郑筱萸. 中药新药临床研究指导原则[S]. 北京: 中国医药科技出版社, 2002: 135-136.
|
| [6] |
赵晓晓, 谢佳平, 赵景润, 等. 复发性反流性食管炎内镜特征的临床对比研究[J]. 中华消化内镜杂志, 2020, 37(1): 45-47. doi: 10.3760/cma.j.issn.1007-5232.2020.01.010
|
| [7] |
梁笑楠, 战蓉蓉, 张晓岚. 《2020年中国胃食管反流病专家共识》解读[J]. 河北医科大学学报, 2021, 42(8): 869-871. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYX202108002.htm
|
| [8] |
杜明慧. 利用数据库分析胃食管反流病的发病因素与临床特点[J]. 现代医学与健康研究电子杂志, 2018, 2(10): 42-42.
|
| [9] |
贾宁, 唐艳萍, 李杨. 现代医学对胃食管反流病研究机制进展[J]. 中国中西医结合外科杂志, 2020, 26(1): 179-183. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZX202001047.htm
|
| [10] |
周玉军, 何凤芝. 对比雷贝拉唑与雷尼替丁在非糜烂性胃食管反流病中的疗效[J]. 中国实用医药, 2021, 16(3): 170-172. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSSA202136063.htm
|
| [11] |
YU LY, SUN LN, ZHANG XH, et al. A review of the novel application and potential adverse effects of proton pump inhibitors[J]. Adv Ther, 2017, 34(5): 1070-1086. doi: 10.1007/s12325-017-0532-9
|
| [12] |
NAITO Y, KASHIWAGI K, TAKAGI T, et al. Intestinal dysbiosis secondary to Proton pump inhibitor use[J]. Digestion, 2018, 97(2): 195-204. doi: 10.1159/000481813
|
| [13] |
ORTIZ-GUERRERO G, AMADOR-MUÑOZ D, CALDERÓN-OSPINA C A, et al. Proton pump inhibitors and dementia: physiopathological mechanisms and clinical consequences[J]. Neural Plast, 2018, 2018: 5257285.
|
| [14] |
TAKAHARI K, HARUMA K, OHTANI H, et al. Proton pump inhibitor induction of gastric cobblestone-like lesions in the stomach[J]. Intern Med, 2017, 56(20): 2699-2703. doi: 10.2169/internalmedicine.7964-16
|
| [15] |
FOSSMARK R, MARTINSEN T C, WALDUM H L. Adverse effects of proton pump inhibitors-evidence and plausibility[J]. Int J Mol Sci, 2019, 20(20): 5203. doi: 10.3390/ijms20205203
|
| [16] |
徐致君, 陈莉丽, 杨振斌, 等. 左金加味方治疗肝胃郁热型胃食管反流病的疗效及对脑肠肽的影响[J]. 实用中医内科杂志, 2023, 37(3): 98-101. https://www.cnki.com.cn/Article/CJFDTOTAL-SYZY202303031.htm
|
| [17] |
陈莉丽, 卜平. 不同证型胃食管反流患者脑肠肽特点[J]. 世界华人消化杂志, 2015, 23(31): 5029-5034. https://cdmd.cnki.com.cn/Article/CDMD-10600-1023120745.htm
|
| 1. |
常珍珍，张俊哓，阎保梅，赵净净. 地尔硫?联合美托洛尔治疗冠心病不稳定型心绞痛的效果. 临床医学. 2024(06): 102-104 .
| |
| 2. |
张富山，张宇，蔡俊，黄建领，赵俊涛，刘广文，张伟峰. 地尔硫卓对冠心病心绞痛患者冠状动脉血流储备与血管内皮的影响. 中国循证心血管医学杂志. 2023(03): 325-328 .
| |
| 3. |
李航，刘亚娟. 替罗非班冠状动脉给药对冠心病患者心肌损伤及PCI后预后情况的影响. 临床和实验医学杂志. 2023(22): 2372-2376 .
| |
| 4. |
谢红静. 参松养心胶囊联合美托洛尔治疗冠心病心绞痛的效果及对患者氧化应激指标的影响. 心血管病防治知识. 2023(30): 7-9+13 .
|
© 2020 《实用临床医药杂志》编辑部
Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807
Supported by:
Beijing Renhe Information Technology Co., Ltd.
苏公网安备 32100302010246号
DownLoad: