Effect of low molecular weight heparin calcium combined with low dose aspirin in patients with recurrent miscarriage

Objective To explore the therapeutic effect of low molecular weight heparin calcium combined with low dose aspirin in patients with recurrent miscarriage.

Methods A total of 180 patients with recurrent miscarriage were randomly divided into control group (n=90) and observation group (n=90). The control group was given low-dose aspirin, and the observation group was given low-molecular weight heparin calcium combined with low-dose aspirin. Two groups were treated until 20 weeks gestation and followed up until termination of pregnancy. The prethrombotic status plasminogen activation inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA), antithrombin Ⅲ (AT-Ⅲ) and protein S (PS), coagulation function prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and platelet count (PLT), hormone levels chorionic gonadotropin (HCG), estradiol (E₂) and progesterone (P), pregnancy outcomes and occurrence of adverse reactions between the two groups were observed.

Results After treatment, PAI-1 and t-PA in the observation the group were significantly lower, AT-Ⅲ and PS were significantly higher than those in the control group (P < 0.05); the PT, TT and APTT in the observation group were significantly higher, while FIB and PLT were significantly lower than those in the control group (P < 0.05). The levels of hormone HCG, E₂ and P in the observation group were significantly higher than those in the control group (P < 0.05). The success rate of fetal protection in the observation group was significantly higher than that in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).

Conclusion Low molecular weight heparin calcium combined with low dose aspirin in the treatment of recurrent abortion patients is better. It can improve the prethrombotic state, coagulation function and hormone level of patients, and the success rate of fetal preservation is higher, and the adverse reactions are less.