Efficacy and bacteriostasis of platelet-rich fibrin combined with foam dressing in treating chronic infection wound

Objective To observe the efficacy and bacteriostasis of platelet-rich fibrin (PRF) combined with foam dressing in treating chronic infection wound.

Methods A total of 90 patients with chronic infection wound were selected and randomly divided into control group and experimental group, with 45 cases in each group. The control group was treated with foam dressing, and the experimental group was treated with PRF and foam dressing. The total effective rate and wound recovery condition (the number of dressing changes and reduction in wound area) after 14 days of treatment were compared between the two groups; the pain scores at 3 and 7 days after treatment were compared between the two groups; the bacterial negative conversion rates at 7 and 14 days after treatment as well as the levels of serum white blood cell (WBC), C-reactive protein (CRP), serum procalcitonin (PCT) and serum interleukin-6 (IL-6) at 14 days after treatment were compared between two groups.

Results After 14 days of treatment, the total effective rate of the experimental group and the control group was 100.00% and 77.78%, respectively, with a significant between-group difference (P < 0.05); after treatment, the number of dressing changes in the experimental group and control group was (4.39±5.48) and (11.12±1.36), respectively, with a significant between-group difference (P < 0.05); the reduction in wound area in the experimental group and the control group was (14.98±1.73) cm² and (11.26±1.35) cm² respectively, with a significant between-group difference (P < 0.05); the pain score of the experimental group was significantly lower than that of the control group at 3 and 7 days after treatment (P < 0.05); at 14 days after treatment, the bacterial negative conversion rates in the experimental group and the control group were 100.00% and 58.62% respectively, with a significant between-group difference (P < 0.05); at 14 days after treatment, the levels of WBC, CRP, PCT and IL-6 in the experimental group were significantly lower than those in the control group (P < 0.05).

Conclusion PRF combined with foam dressing can significantly enhance efficacy in the treatment of chronic infection wound, promote wound healing, relieve pain, inhibit bacterial infections and alleviate the inflammatory reactions.