Correlations of brachial-ankle pulse wave conduction velocity, ankle-brachial index and dynamic arterial stiffness index with left ventricular diastole in coronary heart disease

Objective To investigate the correlations of brachial-ankle pulse wave velocity (baPWV), ankle brachial index (ABI), dynamic arterial stiffness index (AASI) with left ventricular diastolic function in elderly patients with coronary heart disease.

Methods The clinical data of 87 elderly patients with coronary heart disease were analyzed retrospectively, and were selected as study group, and 50 elderly patients with coronary angiography were selected as control group. A total of 87 patients were divided into group A(47 cases) and group B(40 cases) according to whether they had left ventricular diastolic dysfunction, and they were divided into group C (41 cases) and group D (46 cases) according to the presence of hypertension. The difference of baPWV, ABI, AASI indicators in different groups of patients were compared. Pearson correlation analysis was used to analyze the relationships of baPWV, ABI, AASI indicators with left ventricular diastolic function. The receiver operator characteristic (ROC) curve was used to analyze the diagnostic value of baPWV, ABI, AASI for left ventricular diastolic dysfunction.

Results The levels of baPWV and AASI in the study group were significantly higher than those in the control group, and the level of ABI was significantly lower than those in the control group(P < 0.05); the level of baPWV and AASI in group A was significantly higher than that in group B, and the level of ABI was significantly lower than that in group B(P < 0.05). The baPWV, ABI and AASI in group C showed no difference compared with group D (P>0.05). Pearson correlation analysis showed that left ventricular diastolic function was negatively correlated with baPWV and AASI (r=-0.835, r=-0.381, P < 0.05), and positively correlated with ABI (r=0.617, P < 0.05). ROC curve showed that the area under the cerve of baPWV, ABI and AASI in diagnosing left ventricular diastolic dysfunction was 0.983, 0.861 and 0.711, respectively, with sensitivity of 95.7%, 87.2% and 44.7%, specificity of 97.5%, 77.5% and 100.0%.

Conclusion The elderly patients with coronary heart disease show increased levels of baPWV and AASI and decreased ABI, and are more obvious in left ventricular diastolic dysfunction. The baPWV, ABI and AASI are correlated with left ventricular diastolic function, which can effectively predict left ventricular function in elderly patients with coronary heart disease.