| Citation: |
XU Yinghua, YU Hualin, LI Wei, ZHU Xiaohong. Effect of radiotherapy on lymphocytes and their subpopulations in peripheral blood in patients with acquired immune deficiency syndrome complicated with malignant tumors[J]. Journal of Clinical Medicine in Practice, 2023, 27(17): 35-39. DOI: 10.7619/jcmp.20231662
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To explore the effect of radiotherapy on lymphocytes in peripheral blood before and after chemoradiotherapy in patients with acquired immune deficiency syndrome (AIDS) complicated with malignant tumors.
From June 2017 to June 2022, a total of 18 AIDS patients with malignant tumors in authors' hospital were selected as observation group; 18 non-AIDS patients with malignant tumors were selected as control group; 18 healthy people with physical examinations were selected as healthy control group. Flow cytometry was used to detect the cell ratios of CD4+ and CD8+ in peripheral blood in each group, and the ratio of CD4+ to CD8+ (CD4+/CD8+) was calculated. The regression of tumors after 6 months of treatment was compared between groups.
Compared with the healthy control group, the CD4+ and CD4+/CD8+ in peripheral blood in the control group and the observation group decreased significantly, while the CD8+ increased significantly (P < 0.05); compared with the control group, the CD8+ increased significantly, while the CD4+/CD8+ decreased significantly in peripheral blood in the observation group (P < 0.05). One month after radiotherapy, the CD8+ in peripheral blood in the observation group was significantly higher than that in the control group (P < 0.05). Three months after radiotherapy, the CD4+ and CD4+/CD8+ in peripheral blood in the observation group were lower than those in the control group, but there were no significant differences between two groups (P>0.05); the CD8+ in peripheral blood in the observation group was slightly higher than that in the control group, and there was no significant difference between twogroups (P>0.05). In the intragroup comparison in the control group, the CD4+/CD8+ in peripheral blood at one month after radiotherapy was significantly lower than that before radiotherapy, while CD8+ was significantly higher than that before radiotherapy (P < 0.05); there were no significant differences in CD4+, CD8+ and CD4+/CD8+ in the peripheral blood between each time point in the observation group (P>0.05). After 6 months, CT or magnetic resonance imaging was re-examined. In the observation group, there were 10 cases with reduced or no change in tumor tissue, 5 cases with increased tumor tissue or lymph node metastasis, and 3 cases with new metastatic lesions except for lymph nodes; in the control group, there were 13 cases with reduced or no change in tumor tissue, 4 cases with increased tumor tissue or lymph node metastasis, and 1 case with new metastatic lesions except for lymph nodes. There was no significant difference in regression of tumor between the observation group and the control group (P>0.05).
The effect of radiotherapy on the lymphocyte subpopulations in AIDS patients with malignant tumors shows no significant difference compared with those of non-AIDS patients with malignant tumors. Therefore, radiotherapy should be more frequently applied in the treatment of AIDS patients with malignant tumors.
| [1] |
SEZGIN E, VAN NATTA M L, THORNE J E, et al. Secular trends in opportunistic infections, cancers and mortality in patients with AIDS during the era of modern combination antiretroviral therapy[J]. HIV Med, 2018, 19(6): 411-419. doi: 10.1111/hiv.12609
|
| [2] |
VALENCIA ORTEGA M E. Malignancies and infection due to the human immunodeficiency virus. Are these emerging diseases[J]. Rev Clin Esp, 2018, 218(3): 149-155. doi: 10.1016/j.rce.2017.07.011
|
| [3] |
尹科, 何盛华, 范水芬, 等. 高效抗逆转录病毒对艾滋病患者外周血T淋巴细胞亚群水平及生存质量的影响[J]. 川北医学院学报, 2019, 34(1): 9-11. https://www.cnki.com.cn/Article/CJFDTOTAL-NOTH201901003.htm
|
| [4] |
杨婧, 高劲, 肖亮, 等. 调强放疗前后外周血淋巴细胞及其亚群的变化分析[J]. 安徽医科大学学报, 2019, 54(1): 102-107. https://www.cnki.com.cn/Article/CJFDTOTAL-YIKE201901020.htm
|
| [5] |
SIMON DAVIS D A, ATMOSUKARTO I I, GARRETT J, et al. Irradiation immunity interactions[J]. J Med Imaging Radiat Oncol, 2022, 66(4): 519-535. doi: 10.1111/1754-9485.13399
|
| [6] |
XIONG W, LIU Z G, XIONG L, et al. CD3+, CD4+, and CD8+ expression in cells in peripheral blood of silicosis patients and intervention effect of thymalfasin[J]. Ann Clin Lab Sci, 2019, 49(3): 368-371.
|
| [7] |
李露, 罗春香, 董超. 艾滋病相关肿瘤的研究进展[J]. 中国临床医生杂志, 2018, 46(2): 140-143. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLYS201802007.htm
|
| [8] |
MELO G C, CARVALHO A C A, MENDES M L T, et al. Association between frailty phenotype, quantification of plasma HIV-1 RNA, CD4 cell count and HAART in HIV-positive subjects: a systematic review and meta-analysis of observational studies[J]. AIDS Care, 2022, 34(9): 1159-1168. doi: 10.1080/09540121.2021.1956414
|
| [9] |
BORST J, AHRENDS T, BABAŁA N, et al. CD4+ T cell help in cancer immunology and immunotherapy[J]. Nat Rev Immunol, 2018, 18(10): 635-647. doi: 10.1038/s41577-018-0044-0
|
| [10] |
BAE, BRUMBAUGH J, BONAVIDA B. Exosomes derived from cancerous and non-cancerous cells regulate the anti-tumor response in the tumor microenvironment[J]. Genes Cancer, 2018, 9(3/4): 87-100.
|
| [11] |
ARRIETA O, MONTES-SERVÍN E, HERNANDEZ-MARTINEZ J M, et al. Expression of PD-1/PD-L1 and PD-L2 in peripheral T-cells from non-small cell lung cancer patients[J]. Oncotarget, 2017, 8(60): 101994-102005. doi: 10.18632/oncotarget.22025
|
| [12] |
彭强, 董柱清, 徐惠娟. 食管鳞癌患者放疗前后SCC、CRFRA21-1、CA199及T淋巴细胞亚群的变化研究[J]. 中外医学研究, 2017, 15(21): 56-57. https://www.cnki.com.cn/Article/CJFDTOTAL-YJZY201721029.htm
|
| [13] |
JAVADI S, MENIAS C O, KARBASIAN N, et al. HIV-related malignancies and mimics: imaging findings and management[J]. Radiographics, 2018, 38(7): 2051-2068.
|
| [14] |
钟明, 宋毅杰, 王宁, 等. 719例HIV感染/AIDS合并恶性肿瘤的流行病学特征分析[J]. 新发传染病电子杂志, 2022, 7(3): 60-63. https://www.cnki.com.cn/Article/CJFDTOTAL-XFCR202203013.htm
|
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