Effects of chloroquine drugs on ionic channels of myocardial cells

LIU Xinli; LIANG Hao; XU Zhengxin

doi:10.7619/jcmp.20230562

Journal of Clinical Medicine in Practice > 2023 > 27(23): 135-138, 148. > DOI: 10.7619/jcmp.20230562

LIU Xinli, LIANG Hao, XU Zhengxin. Effects of chloroquine drugs on ionic channels of myocardial cells[J]. Journal of Clinical Medicine in Practice, 2023, 27(23): 135-138, 148. DOI: 10.7619/jcmp.20230562

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Effects of chloroquine drugs on ionic channels of myocardial cells

LIU Xinli¹,
LIANG Hao¹,
XU Zhengxin^{1, 2, 3, 4, ,}

1.
Medical College of Yangzhou University, Yangzhou, Jiangsu, 225000
2.
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225001
3.
Key Laboratory of Integrative Medicine Prevention and Treatment for Senile Diseases in Jiangsu Province, Yangzhou, Jiangsu, 225001
4.
Jiangsu Key Laboratory of Noncoding RNA Basic and Clinical Transformation, Yangzhou, Jiangsu, 225009

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Received Date: February 26, 2023
Revised Date: June 10, 2023
Available Online: December 25, 2023

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Abstract

Abstract

Chloroquine has played a pivotal role in the treatment of malaria. Recently, with the development of clinical application, they are increasingly recognized for their effectiveness in other aspects, such as anti-inflammation, immunosuppression, anti-amoebic effects and so on. In the outbreak of the new coronavirus infection, chloroquine and its derivative hydroxychloroquine swiftly included in the treatment of infected patients in many countries. However, several studies have shown these drugs have some detrimental influence, especially in cardiac arrhythmia (prolonged the QT interval and increased risk of torsional ventricular tachycardia). Thus, we should pay attention to both their beneficial effects and potential adverse manifestation. In order to regulate the use of drugs and guide the clinic, this paper reviewed the electrophysiological basis and clinical characteristics of cardiac adverse reactions of these drugs from the perspective of ion channels.
- chloroquine,
- cardiotoxin,
- arrhythmia,
- ion channels

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References (43)

References

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