Effect of Tongxinluo Capsule on restenosis and serum inflammatory factors after carotid artery stenting

Objective  To explore the effects of Tongxinluo Capsule on restenosis and serum inflammatory factors after carotid artery stenting.

Methods  A total of 90 patients with carotid artery stenting were randomly divided into observation group and control group, with 45 cases in each group. Both groups were conducted with conventional treatment, while the observation group was given additional Tongxinluo Capsule for treatment. The levels of serum inflammatory factors C reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), vascular endothelial function indexes vascular endothelial growth factor (VEGF), endothelin-1 (ET-1) and nitric oxide (NO), hemodynamics indexescarotid intima-media thickness (IMT), peak systolic blood flow velocity (SV), peak diastolic blood flow velocity (DV) and vascular resistance index (RI), incidence of cardiocerebral vascular events, and the incidence of restenosis after carotid artery stenting were compared between two groups.

Results  After half a year of treatment, the levels of CRP, TNF-α and IL-6 in the observation group were significantly lower than those in the control group (P < 0.05); the levels of VEGF and ET-1 in the observation group were significantly lower than those in the control group, while the level of NO was significantly higher than that in the control group (P < 0.05); the levels of IMT and RI in the observation group were significantly lower than those in the control group, while the levels of SV and DV were significantly higher than those in the control group (P < 0.05). The incidence of cardiocerebral vascular events in the observation group was 4.44%, which showed no significant difference when compared to 13.33% in the control group (P > 0.05). The incidence of postoperative restenosis in the observation group was 4.44%, which was significantly lower than 17.78% in the control group (P < 0.05).

Conclusion  The application of Tongxinluo Capsule after carotid artery stenting can delay the progression of atherosclerosis and reduce the degree of inflammatory reaction of patients, which is worthy of popularization and promotion.