DENG Longlian, SUN Haibin, Enri-Letu, WANG Tengqi. Research progresses of nomogram in predicting lymph node metastasis of colorectal cancer[J]. Journal of Clinical Medicine in Practice, 2023, 27(5): 143-148. DOI: 10.7619/jcmp.20223328
Citation: DENG Longlian, SUN Haibin, Enri-Letu, WANG Tengqi. Research progresses of nomogram in predicting lymph node metastasis of colorectal cancer[J]. Journal of Clinical Medicine in Practice, 2023, 27(5): 143-148. DOI: 10.7619/jcmp.20223328

Research progresses of nomogram in predicting lymph node metastasis of colorectal cancer

More Information
  • Received Date: November 07, 2022
  • Revised Date: November 08, 2022
  • Available Online: April 06, 2023
  • Lymph node metastasis (LNM) affects the choice of treatment and prognosis of patients with colorectal cancer (CRC), and how to predict lymph node status more accurately is a major challenge in the field of CRC. As a visual prediction model, nomogram has been widely studied in the field of lymph node metastasis of colorectal cancer (CRC-LNM) prediction in recent years. Nomogram based on clinical features, radiology, genomic or transcriptomic features is significantly better than traditional TNM staging in identifying LNM preoperatively, which provides a basis for healthcare professionals to more accurately identify LNM high-risk groups and develop personalized treatment strategies. Non-invasive blood tests can obtain non-invasive, convenient, and inexpensive preoperative acquisition of circulating tumor biomarkers, and the construction of nomograms and prediction of LNM is promising. The interdisciplinary study combining clinical, radiology, and circulating markers can help further improve the predictive performance of nomograms and deserves further investigation.

  • [1]
    BRAY F, FERLAY J, SOERJOMATARAM I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6): 394-424. doi: 10.3322/caac.21492
    [2]
    SUNG H, FERLAY J, SIEGEL R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. doi: 10.3322/caac.21660
    [3]
    中华人民共和国国家卫生健康委员会医政医管局, 中华医学会肿瘤学分会. 中国结直肠癌诊疗规范(2020年版)[J]. 中国实用外科杂志, 2020, 40(6): 601-625. doi: 10.19538/j.cjps.issn1005-2208.2020.06.01
    [4]
    DE GOOYER J M, VERSTEGEN M G, LAM-BOER J, et al. Neoadjuvant chemotherapy for locally advanced T4 colon cancer: a nationwide propensity-score matched cohort analysis[J]. Dig Surg, 2020, 37(4): 292-301. doi: 10.1159/000503446
    [5]
    YANG Z F, LI Y, QIN X S, et al. Development and validation of a prognostic nomogram for colorectal cancer patients with synchronous peritoneal metastasis[J]. Front Oncol, 2021, 11: 615321. doi: 10.3389/fonc.2021.615321
    [6]
    XIONG Y F, YOU W X, HOU M, et al. Nomogram integrating genomics with clinicopathologic features improves prognosis prediction for colorectal cancer[J]. Mol Cancer Res, 2018, 16(9): 1373-1384. doi: 10.1158/1541-7786.MCR-18-0063
    [7]
    刘书霞, 张磊, 石远凯, 等. 非转移性结直肠癌患者术后预后影响因素分析及列线图预测模型的构建[J]. 中华肿瘤杂志, 2022, 44(2): 167-172.
    [8]
    HU D Y, CAO B, LI S H, et al. Incidence, risk factors, and a predictive model for lymph node metastasis of submucosal (T1) colon cancer: a population-based study[J]. J Dig Dis, 2019, 20(6): 288-293. doi: 10.1111/1751-2980.12754
    [9]
    OH J R, PARK B, LEE S, et al. Nomogram development and external validation for predicting the risk of lymph node metastasis in T1 colorectal cancer[J]. Cancer Res Treat, 2019, 51(4): 1275-1284. doi: 10.4143/crt.2018.569
    [10]
    XU Y S, CHEN Y, LONG C Y, et al. Preoperative predictors of lymph node metastasis in colon cancer[J]. Front Oncol, 2021, 11: 667477. doi: 10.3389/fonc.2021.667477
    [11]
    WADA Y M, SHIMADA M, MURANO T, et al. A liquid biopsy assay for noninvasive identification of lymph node metastases in T1 colorectal cancer[J]. Gastroenterology, 2021, 161(1): 151-162, e1. doi: 10.1053/j.gastro.2021.03.062
    [12]
    武杰, 李岚, 张惠博, 等. 结肠癌淋巴结转移的风险基因及列线图预测模型的构建[J]. 肿瘤防治研究, 2020, 47(12): 947-952. doi: 10.3971/j.issn.1000-8578.2020.20.0234
    [13]
    HUANG Y Q, LIANG C H, HE L, et al. Development and validation of a radiomics nomogram for preoperative prediction of lymph node metastasis in colorectal cancer[J]. J Clin Oncol, 2016, 34(18): 2157-2164. doi: 10.1200/JCO.2015.65.9128
    [14]
    COLLINS G S, REITSMA J B, ALTMAN D G, et al. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement[J]. BMJ, 2015, 350: g7594. doi: 10.1136/bmj.g7594
    [15]
    RILEY R D, ENSOR J, SNELL K I E, et al. Calculating the sample size required for developing a clinical prediction model[J]. BMJ, 2020, 368: m441.
    [16]
    ZHOU Z R, WANG W W, LI Y, et al. In-depth mining of clinical data: the construction of clinical prediction model with R[J]. Ann Transl Med, 2019, 7(23): 796. doi: 10.21037/atm.2019.08.63
    [17]
    郭源, 李云龙, 张龙, 等. T3、T4期结直肠癌淋巴结转移危险因素分析[J]. 肿瘤研究与临床, 2020, 32(3): 161-165. doi: 10.3760/cma.j.cn115355-20190405-00125
    [18]
    庄奥博, 朱德祥, 许平平, 等. T1期结直肠癌淋巴结转移的危险因素分析及其列线图预测模型的应用价值[J]. 中华消化外科杂志, 2021, 20(3): 323-330. doi: 10.3760/cma.j.cn115610-20210224-00096
    [19]
    德吉, 秦金玉, 王瑾, 等. 早期结直肠癌淋巴结转移的危险因素分析及内镜切除指征的探讨[J]. 中华消化内镜杂志, 2015, 32(6): 367-370. doi: 10.3760/cma.j.issn.1007-5232.2015.06.003
    [20]
    MUTO T, OYA M. Recent advances in diagnosis and treatment of colorectal T1 carcinoma[J]. Dis Colon Rectum, 2003, 46(10 Suppl): S89-S93.
    [21]
    NASCIMBENI R, BURGART L J, NIVATVONGS S, et al. Risk of lymph node metastasis in T1 carcinoma of the colon and rectum[J]. Dis Colon Rectum, 2002, 45(2): 200-206. doi: 10.1007/s10350-004-6147-7
    [22]
    LIU Z T, HUANG C, TIAN H K, et al. Establishment of a dynamic nomogram for predicting the risk of lymph node metastasis in T1 stage colorectal cancer[J]. Front Surg, 2022, 9: 845666. doi: 10.3389/fsurg.2022.845666
    [23]
    FU J P, TU M J, ZHANG Y, et al. A model of multiple tumor marker for lymph node metastasis assessment in colorectal cancer: a retrospective study[J]. PeerJ, 2022, 10: e13196. doi: 10.7717/peerj.13196
    [24]
    LONG C Y, FENG M Y, WANG S J, et al. A clinicopathological feature-based nomogram for predicting the likelihood of D3 lymph node metastasis in right-sided colon cancer patients[J]. Dis Colon Rectum, 2023, 66(1): 75-86. doi: 10.1097/DCR.0000000000002160
    [25]
    吕智豪, 刘华熙, 郭昌, 等. 联合检测肿瘤标志物与炎症指标对结直肠癌的诊断价值[J]. 中国现代医学杂志, 2020, 30(1): 56-62. doi: 10.3969/j.issn.1005-8982.2020.01.011
    [26]
    GILLIES R J, KINAHAN P E, HRICAK H. Radiomics: images are more than pictures, they are data[J]. Radiology, 2016, 278(2): 563-577. doi: 10.1148/radiol.2015151169
    [27]
    XU X, ZHANG H L, LIU Q P, et al. Radiomic analysis of contrast-enhanced CT predicts microvascular invasion and outcome in hepatocellular carcinoma[J]. J Hepatol, 2019, 70(6): 1133-1144. doi: 10.1016/j.jhep.2019.02.023
    [28]
    MAYERHOEFER M E, MATERKA A, LANGS G, et al. Introduction to radiomics[J]. J Nucl Med, 2020, 61(4): 488-495. doi: 10.2967/jnumed.118.222893
    [29]
    LI M L, ZHANG J, DAN Y B, et al. A clinical-radiomics nomogram for the preoperative prediction of lymph node metastasis in colorectal cancer[J]. J Transl Med, 2020, 18(1): 46. doi: 10.1186/s12967-020-02215-0
    [30]
    CHENG Y, YU Q, MENG W Y, et al. Clinico-radiologic nomogram using multiphase CT to predict lymph node metastasis in colon cancer[J]. Mol Imaging Biol, 2022, 24(5): 798-806. doi: 10.1007/s11307-022-01730-4
    [31]
    ZHOU Y, YANG R, WANG Y, et al. Histogram analysis of diffusion-weighted magnetic resonance imaging as a biomarker to predict LNM in T3 stage rectal carcinoma[J]. BMC Med Imaging, 2021, 21(1): 176. doi: 10.1186/s12880-021-00706-0
    [32]
    CHEN L D, LIANG J Y, WU H, et al. Multiparametric radiomics improve prediction of lymph node metastasis of rectal cancer compared with conventional radiomics[J]. Life Sci, 2018, 208: 55-63. doi: 10.1016/j.lfs.2018.07.007
    [33]
    HE J H, WANG Q S, ZHANG Y, et al. Preoperative prediction of regional lymph node metastasis of colorectal cancer based on (18)F-FDG PET/CT and machine learning[J]. Ann Nucl Med, 2021, 35(5): 617-627. doi: 10.1007/s12149-021-01605-8
    [34]
    OZAWA T, KANDIMALLA R, GAO F, et al. A microRNA signature associated with metastasis of T1 colorectal cancers to lymph nodes[J]. Gastroenterology, 2018, 154(4): 844-848, e7. doi: 10.1053/j.gastro.2017.11.275
    [35]
    KANDIMALLA R, OZAWA T, GAO F, et al. Gene expression signature in surgical tissues and endoscopic biopsies identifies high-risk T1 colorectal cancers[J]. Gastroenterology, 2019, 156(8): 2338-2341, e3. doi: 10.1053/j.gastro.2019.02.027
    [36]
    QU A L, YANG Y M, ZHANG X, et al. Development of a preoperative prediction nomogram for lymph node metastasis in colorectal cancer based on a novel serum miRNA signature and CT scans[J]. EBioMedicine, 2018, 37: 125-133. doi: 10.1016/j.ebiom.2018.09.052
  • Related Articles

    [1]LI Jia, WANG Lin, LIU Nan, WANG Ting, ZHAO Xiaoya, GAO Lini, ZHAO Ping. Effect of mindfulness training on sleep quality and psychological state of perimenopausal patients with insomnia[J]. Journal of Clinical Medicine in Practice, 2022, 26(23): 85-88. DOI: 10.7619/jcmp.20222790
    [2]LIN Yan, ZHOU Ping, LI Yanzhen, LI Shiting. Effect of preoperative anxiety and depression and sleep qualityon sequelae of Bell's palsy and its intervention strategy[J]. Journal of Clinical Medicine in Practice, 2021, 25(7): 30-33. DOI: 10.7619/jcmp.20201495
    [3]XI Lijuan, WANG Daorong, FANG Fang, YUAN Haijuan. Mediating effect of depression on sleep and preoperative frailty in elderly patients with gastrointestinal cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(5): 50-54. DOI: 10.7619/jcmp.20201747
    [4]ZHANG Zhanhua, TIAN Feng. Expression of serum cortisol levels in post-stroke depression patients before and after treatment and its correlation with depression[J]. Journal of Clinical Medicine in Practice, 2019, 23(24): 34-36. DOI: 10.7619/jcmp.201924011
    [5]MEI Jing, WANG Chungang, BO Lin. Effect of SSRI anti depression drugs combined with conventional drugs for cerebral vascular disease on treatment of patients with post stroke depression[J]. Journal of Clinical Medicine in Practice, 2017, (1): 25-27. DOI: 10.7619/jcmp.201701007
    [6]CHEN Rende. The effect of duloxetine on sleeping quality of elderly female patients with depression[J]. Journal of Clinical Medicine in Practice, 2015, (Z1): 159-160.
    [7]JIA Jing, QIANG Xiaoling. Influence of comprehensive nursing interventions on depressive emotion and QOL in patients with depression[J]. Journal of Clinical Medicine in Practice, 2015, (16): 14-16. DOI: 10.7619/jcmp.201516005
    [8]QIU Yanli. The influence of psychological nursing intervention combined with massage on postpartum depression of patients[J]. Journal of Clinical Medicine in Practice, 2015, (2): 77-79,83. DOI: 10.7619/jcmp.201502024
    [9]Study on the relationship between quality of life and self-efficacy of patients with depressive disorder[J]. Journal of Clinical Medicine in Practice, 2014, (20): 15-18. DOI: 10.7619/jcmp.201420005
    [10]SONG Wenying. Influence of nursing intervention on the quality of life of patients with depression[J]. Journal of Clinical Medicine in Practice, 2013, (16): 147-149. DOI: 10.7619/jcmp.201316057
  • Cited by

    Periodical cited type(25)

    1. 刘珊励,刘金叶,陈叶奇. 甘精胰岛素与预混胰岛素分别联合阿卡波糖对2型糖尿病患者血糖控制及胰岛素用量的影响. 糖尿病新世界. 2024(15): 91-94 .
    2. 佘其美,董亚苒,王新芳,玉晓露,程景丽,裴倩倩,谷贵燕,李湘. 分析甘精胰岛素联合磷酸西格列汀治疗老年2型糖尿病(T2DM)的临床效果. 糖尿病新世界. 2023(04): 116-119+123 .
    3. 魏伟. 甘精胰岛素联合重组人胰岛素强化治疗2型糖尿病的临床效果. 临床合理用药. 2023(23): 98-101 .
    4. 毛财凤. 甘精胰岛素联合口服降糖药治疗血糖控制不佳的2型糖尿病患者的临床效果. 中国医学创新. 2023(25): 16-20 .
    5. 郑清华,时维琼,刘慧丽. 胰岛素联合平衡盐溶液对老年重度糖尿病酮症酸中毒患者β2微球蛋白、FT4水平的影响. 中国老年学杂志. 2022(08): 1816-1819 .
    6. 刘利. 利格列汀联合度拉糖肽对2型糖尿病患者临床疗效研究. 天津药学. 2022(02): 63-65+71 .
    7. 陈钦榜,何英. 阿卡波糖联合甘精胰岛素对2型糖尿病患者的疗效及不良反应的影响. 糖尿病新世界. 2022(13): 81-84 .
    8. 张魁星. 甘精胰岛素联合二甲双胍治疗2型糖尿病的效果分析. 现代诊断与治疗. 2022(18): 2717-2719 .
    9. 张子毅,郭静超. 甘精胰岛素联合二甲双胍对初发2型糖尿病患者血糖水平和胰岛β功能的影响. 实用糖尿病杂志. 2021(01): 99-100 .
    10. 王利平. 阿卡波糖和胰岛素治疗老年2型糖尿病的效果和安全性. 中国当代医药. 2021(11): 76-78 .
    11. 冯聪. 2型糖尿病应用长效胰岛素联合口服降糖药治疗的有效性研究. 中国实用医药. 2021(20): 136-138 .
    12. 黄新峰. 2型糖尿病治疗中甘精胰岛素联合瑞格列奈的应用安全性分析. 黑龙江中医药. 2021(04): 35-36 .
    13. 房思思. 长效胰岛素联合口服降糖药治疗2型糖尿病的疗效与安全性. 中国实用医药. 2021(27): 114-116 .
    14. 汪俊. 甲巯咪唑联合甘精胰岛素对糖尿病伴甲亢的疗效分析. 医学食疗与健康. 2021(08): 58-59 .
    15. 李华荣,余婷. 麦味地黄汤加减联合消渴丸治疗2型糖尿病临床效果观察. 现代诊断与治疗. 2021(21): 3380-3381 .
    16. 林小玲. 甘精胰岛素联合阿卡波糖治疗老年糖尿病的临床疗效及安全性分析. 中国现代药物应用. 2020(09): 170-171 .
    17. 陈维平,谢芸. 沙格列汀联合胰岛素用药在2型糖尿病治疗中的临床作用. 中外医学研究. 2020(15): 136-138 .
    18. 何德卓. 甘精胰岛素联合阿卡波糖治疗2型糖尿病临床观察. 北方药学. 2020(06): 104-105 .
    19. 张明谦. 甘精胰岛素和预混胰岛素治疗2型糖尿病的临床效果比较. 福建医药杂志. 2020(03): 174-175 .
    20. 林玉平. 甘精胰岛素联合门冬胰岛素治疗对T2DM患者的血糖控制效果. 海峡药学. 2020(08): 190-192 .
    21. 龙爱梅,武红梅,邓丽萍,黄妙玲,何圣清,张帆. 甘精胰岛素和预混胰岛素分别联合阿卡波糖治疗2型糖尿病效果差异. 中国处方药. 2020(10): 105-106 .
    22. 王玲,赵岚. 糖尿病患者阿卡波糖治疗的临床疗效研究进展. 实用心脑肺血管病杂志. 2020(S1): 282-283 .
    23. 孙景. 甘精胰岛素联合瑞格列奈治疗2型糖尿病的价值研究. 海峡药学. 2020(10): 155-156 .
    24. 张琼珍. 预混胰岛素类似物与基础胰岛素对128例2型糖尿病患者起始胰岛素治疗的临床疗效分析. 糖尿病新世界. 2020(22): 34-36 .
    25. 何燕. 基础胰岛素联合阿卡波糖对比预混胰岛素治疗2型糖尿病的临床效果分析. 糖尿病新世界. 2020(24): 94-96 .

    Other cited types(0)

Catalog

    Article views (246) PDF downloads (21) Cited by(25)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return