Objective To investigate the expression characteristics and detection value of histamine (HA), soluble myeloid cell trigger receptor-1 (sTREM-1), microribonuclease-145 (miR-145) and hypersensitive C-reactive protein (hs-CRP) in patients with chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD).
Methods A total of 107 healthy people with COPD and CHD were selected as study group, and 107 healthy people with physical examinations in the same period were selected as control group. The blood samples of the subjects were taken to measure the levels of miR-145, HA, sTREM-1 and hs-CRP. The levels of HA, sTREM-1, miR-145 and hs-CRP in the study group and the control group were compared, and their levels in different disease severity and different New York Heart Association(NYHA) grades were compared, and the correlations of the level of each indicator with the disease severity and NYHA grades were observed.
Results The levels of HA, sTREM-1 and hs-CRP in the study group were higher than those in the control group, and the level of miR-145 was lower than those in the control group (P < 0.05). The levels of HA, sTREM-1, miR-145 and hs-CRP in patients with different degrees of COPD showed significant difference, and with increase of the severity of the disease, HA, sTREM-1 and hs-CRP continued to increase, while miR-145 continued to decrease (P < 0.05). The levels of HA, sTREM-1, miR-145 and hs-CRP in different NYHA grades showed significant differences, and with the increase of NYHA grades, HA, sTREM-1 and hs-CRP continued to increase, while miR-145 continued to decrease (P < 0.05). HA, sTREM-1, hs-CRP were positively correlated with the severity of COPD and NYHA grade, while miR-145 was negatively correlated with the severity of COPD and NYHA grade (P < 0.05).
Conclusion The expression of HA, sTREM-1, miR-145 and hs-CRP are abnormal in patients with COPD and CHD, which is closely related to the severity of COPD and NYHA grade.
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