Objective To investigate the changes of left ventricular myocardial work in patients with metabolic syndrome (MS) assessed by pressure-strain loops (PSL).
Methods Sixty-eight patients with MS were included in study group, and 50 patients with healthy physical examination during the same period were included in control group. No left ventricular remodeling occurred in all MS patients. Left ventricular parameters were evaluated by echocardiography and left ventricular mass index (LVMI) was calculated. PSL was used to measure Global Work Index (GWI), Global Work Efficiency (GWE), Global Constructive Work (GCW), Global Work Waste (GWW) and other parameters of global left ventricular myocardial work. The changes of global left ventricular work parameters and echocardiographic parameters were compared between the two groups.
Results There were no significant differences in height, gender, age and body surface area between the two groups (P>0.05), while there were significant differences in body mass, body mass index, blood pressure, blood glucose and blood lipid indexes between the two groups (P < 0.05). There were no significant differences in left ventricular end-diastolic diameter (LVEDd) and left ventricular ejection fraction (LVEF) between the two groups (P>0.05). There were statistically significant differences in left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular posterior wall thickness at end diastole (LVPWTd), interventricular septal wall thickness at end diastole (IVSTd) and LVMI between the two groups (P < 0.05). Compared with the control group, GWI, GWE, GCW and GLS of the study group were significantly lower than those of the control group, while GWW was significantly higher than that of the control group (P < 0.05). Pearson analysis showed that GWI, GWE and GCW were positively correlated with GLS (r=0.81, 0.79, 0.75, P < 0.01), while GWW was negatively correlated with GLS (r=-0.71, P < 0.01). GWI, GWE and GCW were positively correlated with LVEF (r=0.68, 0.65, 0.66, P < 0.01), while GWW was negatively correlated with LVEF (r=-0.60, P < 0.01). The intra-group correlation coefficients of GWI, GWE, GCW and GWW were 0.958, 0.927, 0.948 and 0.925, and the inter-group correlation coefficients were 0.918, 0.947, 0.925 and 9.943, respectively.
Conclusion PSL can quantitatively assess changes in left ventricular work in MS patients with good consistency.
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