ZHU Yanan, ZHANG Zhiqiang, ZHU Yunxia. Value of serum angiopoietin-like protein 2 and secreted frizzled-related protein 5 in predicting postoperative coronary slow flow in patients with acute coronary syndrome[J]. Journal of Clinical Medicine in Practice, 2023, 27(3): 11-15, 20. DOI: 10.7619/jcmp.20222734
Citation: ZHU Yanan, ZHANG Zhiqiang, ZHU Yunxia. Value of serum angiopoietin-like protein 2 and secreted frizzled-related protein 5 in predicting postoperative coronary slow flow in patients with acute coronary syndrome[J]. Journal of Clinical Medicine in Practice, 2023, 27(3): 11-15, 20. DOI: 10.7619/jcmp.20222734

Value of serum angiopoietin-like protein 2 and secreted frizzled-related protein 5 in predicting postoperative coronary slow flow in patients with acute coronary syndrome

More Information
  • Received Date: August 31, 2022
  • Available Online: March 01, 2023
  • Objective 

    To explore the value of serum angiopoietin-like protein 2 (ANGPTL2) and secreted frizzled-related protein 5 (SFRP5) levels in predicting coronary slow flow (CSF) after percutaneous coronaryintervention (PCI) in patients with acute coronary syndrome (ACS).

    Methods 

    A total of 182 patients with ACS who underwent PCI were regarded as the research subjects. According to whether the patients developed CSF after PCI, they were grouped into CSF group (42 cases) and normal blood flow group (140 cases). Enzyme-linked immunosorbent assay (ELISA) was performed to detect the levels of serum ANGPTL2 and SFRP5 in ACS patients before PCI. Pearson correlation was performed to analyze the correlation between the levels of serum ANGPTL2 and SFRP5 in the CSF group before PCI. Multivariate Logistic regression was performed to analyze the risk factors of CSF after PCI in ACS patients; receiver operating characteristic (ROC) curve was performed to evaluate the predictive value of levels of serum ANGPTL2 and SFRP5 for CSF in patients with ACS after PCI.

    Results 

    The level of serum ANGPTL2 in the CSF group was (3.48±0.66) ng/mL, which was significantly higher than (2.80±0.51) ng/mL in the normal blood flow group (P < 0.05); the level of serum SFRP5 in the CSF group was (14.85±4.04) ng/mL, which was significantly lower than (22.12±4.69) ng/mL in the normal blood flow group (P < 0.05). There was a significant negative correlation between serum ANGPTL2 and SFRP5 before PCI in CSF group (r=-0.661, P < 0.001). High level of serum ANGPTL2 and low level of SFRP5 before PCI were risk factors for CSF in patients with ACS after PCI. The area under the ROC curve (AUC) of ANGPTL2 and SFRP5 in predicting CSF after PCI was significantly greater than that predicted by ANGPTL2 alone (Z=2.206, P=0.014) and by SFRP5 alone (Z=1.696, P=0.045).

    Conclusion 

    Serum ANGPTL2 and SFRP5 levels are the factors influencing the occurrence of CSF after PCI. The increased level of ANGPTL2 and decreased level of SFRP5 before and after PCI in patients with ACS are associated with the occurrence of CSF after PCI. The combined detection has predictive value for the occurrence of CSF after PCI in patients with ACS.

  • [1]
    DU G L, LUO J Y, WANG D L, et al. MIF gene rs755622 polymorphism positively associated with acute coronary syndrome in Chinese Han population: case-control study[J]. Sci Rep, 2020, 10(1): 140. doi: 10.1038/s41598-019-56949-z
    [2]
    ZHANG X Y, TIAN G H, SHI Z F, et al. Initiate Danhong Injection before or after percutaneous coronary intervention for microvascular obstruction in ST-elevation myocardial infarction (DIRECTION): study protocol for a randomized controlled trial[J]. Trials, 2020, 21(1): 48. doi: 10.1186/s13063-019-3947-6
    [3]
    THORIN-TRESCASES N, LABBÉ P, MURY P, et al. Angptl2 is a marker of cellular senescence: the physiological and pathophysiological impact of Angptl2-related senescence[J]. Int J Mol Sci, 2021, 22(22): 12232. doi: 10.3390/ijms222212232
    [4]
    CAO Y J, LI R Q, ZHANG F P, et al. Correlation between angiopoietin-like proteins in inflammatory mediators in peripheral blood and severity of coronary arterial lesion in patients with acute myocardial infarction[J]. Exp Ther Med, 2019, 17(5): 3495-3500.
    [5]
    NGUYEN A, MAMARBACHI M, TURCOT V, et al. Lower methylation of the ANGPTL2 gene in leukocytes from post-acute coronary syndrome patients[J]. PLoS One, 2016, 11(4): e0153920. doi: 10.1371/journal.pone.0153920
    [6]
    王康, 智丽霞, 石姣姣, 等. 冠心病患者血浆白脂素和分泌型卷曲相关蛋白5与冠状动脉病变程度的相关性[J]. 临床心血管病杂志, 2022, 38(6): 455-460. https://www.cnki.com.cn/Article/CJFDTOTAL-LCXB202206016.htm
    [7]
    DU Y, ZHAO Y X, ZHU Y, et al. High serum secreted frizzled-related protein 5 levels associates with early improvement of cardiac function following ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention[J]. J Atheroscler Thromb, 2019, 26(10): 868-878. doi: 10.5551/jat.47019
    [8]
    HU F, LU F, HUANG X, et al. Relationship between plasma total homocysteine levels and mean corrected TIMI frame count in patients with acute myocardial infarction[J]. Int J Gen Med, 2021, 14: 8161-8172. doi: 10.2147/IJGM.S338938
    [9]
    中国医师协会急诊医师分会, 国家卫健委能力建设与继续教育中心急诊学专家委员会, 中国医疗保健国际交流促进会急诊急救分会. 急性冠状动脉综合征急诊快速诊治指南(2019)[J]. 中国急救医学, 2019, 39(4): 301-308. doi: 10.3969/j.issn.1002-1949.2019.04.001
    [10]
    季鹏, 孙伟, 贾玉卿. IL-16联合GRACE出院评分对老年非ST段抬高型急性冠状动脉综合征病人不良心脑血管事件的预测价值[J]. 实用老年医学, 2021, 35(9): 939-942, 947. doi: 10.3969/j.issn.1003-9198.2021.09.012
    [11]
    胡盛寿, 高润霖, 刘力生, 等. 《中国心血管病报告2018》概要[J]. 中国循环杂志, 2019, 34(3): 209-220. doi: 10.3969/j.issn.1000-3614.2019.03.001
    [12]
    张姝, 赵洪震, 兰海峰. 彩色多普勒超声检测动脉内中膜厚度、血管舒张功能在预测冠心病发生中的价值[J]. 实用临床医药杂志, 2019, 23(6): 17-20. doi: 10.7619/jcmp.201906004
    [13]
    王冲冲, 邓天明, 王艳红. 温胆汤对急性冠状动脉综合征经皮冠状动脉介入术后患者脂蛋白磷脂酶A2的影响[J]. 广州中医药大学学报, 2022, 39(6): 1262-1267. https://www.cnki.com.cn/Article/CJFDTOTAL-REST202206007.htm
    [14]
    俞春霞, 蔡薇. 急性冠脉综合征患者多项生化标志物检测及预后分析[J]. 实用临床医药杂志, 2017, 21(13): 196-197. doi: 10.7619/jcmp.201713068
    [15]
    TASAR O, KARABAY A K, ODUNCU V, et al. Predictors and outcomes of no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention[J]. Coron Artery Dis, 2019, 30(4): 270-276. doi: 10.1097/MCA.0000000000000726
    [16]
    王琰, 李永星, 郭华, 等. 急性心肌梗死急诊经皮冠状动脉介入术后慢血流/无复流的相关因素研究[J]. 中国现代医学杂志, 2022, 32(7): 24-30. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXDY202207017.htm
    [17]
    LI H Y, SUN K, ZHAO R P, et al. Inflammatory biomarkers of coronary heart disease[J]. Front Biosci (Schol Ed), 2018, 10(1): 185-196. doi: 10.2741/s508
    [18]
    林灵丹, 许士达, 邢海燕. 白细胞介素-17预测ST段抬高型心肌梗死患者经皮冠状动脉介入术后慢血流或无复流的价值[J]. 实用临床医药杂志, 2021, 25(11): 93-95, 100. doi: 10.7619/jcmp.20210482
    [19]
    CHEN W G, WANG J B, WANG X H, et al. Knockdown of hypoxia-inducible factor 1-alpha (HIF1α) interferes with angiopoietin-like protein 2 (ANGPTL2) to attenuate high glucose-triggered hypoxia/reoxygenation injury in cardiomyocytes[J]. Bioengineered, 2022, 13(1): 1476-1490.
    [20]
    AKOUMIANAKIS I, SANNA F, MARGARITIS M, et al. Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases[J]. Sci Transl Med, 2019, 11(510): eaav5055.
    [21]
    HUANG X, YAN Y, ZHENG W, et al. Secreted frizzled-related protein 5 protects against cardiac rupture and improves cardiac function through inhibiting mitochondrial dysfunction[J]. Front Cardiovasc Med, 2021, 8: 682409.
    [22]
    TONG S, JI Q W, DU Y, et al. Sfrp5/wnt pathway: a protective regulatory system in atherosclerotic cardiovascular disease[J]. J Interferon Cytokine Res, 2019, 39(8): 472-482.
  • Cited by

    Periodical cited type(28)

    1. 姚金磊,杨帆. 子宫内膜癌手术恐惧现状及其影响因素探究. 罕少疾病杂志. 2025(01): 176-178 .
    2. 张海红. 健康教育标准路径在神经外科患者围手术期中的应用. 中华养生保健. 2025(02): 152-155 .
    3. 鞠齐峰,安月鹏,袁锐,杨素清. 升丹的历史追溯与现代药理应用. 中医药学报. 2024(03): 75-79 .
    4. 徐聪,姚婕,唐丽丽,董卫芹. 揿针联合耳穴埋籽对局部麻醉择期手术下肢静脉曲张患者术前焦虑情绪和生命体征的影响. 新中医. 2024(07): 129-133 .
    5. 舒芳芳,包磊,朱丽群,沈春华,米元元,朱蓓,唐为定,屠海霞,黄燕,赵倩. 成人择期手术术前焦虑非药物管理审查指标的制订及障碍与促进因素分析. 护理研究. 2024(09): 1645-1651 .
    6. 程菲,张铁成,杨黎黎,金伟,刘桂才,孙汉堂. 加速康复外科路径对颌骨囊肿患者围手术期应用效果研究. 交通医学. 2024(02): 211-213 .
    7. 卓银霞,彭晓银,陈桂英,潘欣欣. 动静脉内瘘失功后焦虑对维持性血液透析患者血压的影响. 中国医药导报. 2024(12): 46-49 .
    8. 刘洁,何金凯,张娟,刘青萍,赵玲. 老年慢性鼻—鼻窦炎患者接受功能性鼻内镜手术治疗术前恐惧性焦虑评估及影响因素研究. 老年医学与保健. 2024(04): 1154-1159 .
    9. 侯怀晶,薛建军,丁凡帆,徐紫清,张杰,薛阳,赵晓红,陈丽萍,马丽,杨克虎,赵永强. 《中西医结合防治术后胃肠功能紊乱临床实践指南(2023)》解读. 中华麻醉学杂志. 2024(08): 909-916 .
    10. 罗怡,杨玉娥,林根芳. 基于IMB技巧模型的个性化健康指导在RARP围术期患者中的应用. 浙江临床医学. 2024(09): 1396-1398 .
    11. 罗雯,周润,廖泽霞. 腹腔镜胆囊切除术患者术前焦虑与临床关怀的相关性研究. 当代护士(上旬刊). 2024(10): 139-142 .
    12. 缪志慧,邵晓兰,冯晓梅,崔秀宏,生冬梅. 手术室“温暖护理”在急性结石性胆囊炎患者中的应用. 护理实践与研究. 2024(11): 1727-1733 .
    13. 孟婧文,刘颖. 日间人工流产术患者术前焦虑与信息需求现状及影响因素分析. 北京医学. 2024(09): 772-778 .
    14. 李春华,黄素珍,黄恩娥,林小兰,张美恋,吴伟晴. 超声引导下乳腺肿物微创旋切术患者睡眠质量影响因素调查及护理研究. 世界睡眠医学杂志. 2024(09): 2058-2061 .
    15. 肖颜,陶广华. 择期手术患者术前焦虑状态及其影响因素分析. 护理实践与研究. 2023(01): 37-40 .
    16. 陈俭,程菲,杨黎黎,张铁成. 精细化治疗在颌面外科患者围术期中的应用研究. 南通大学学报(医学版). 2023(01): 70-71 .
    17. 芮爱菊,杨香玉,邢红岩. 作业流程重组健康教育指导模式在胆结石微创手术围手术期的应用价值. 中国医药导报. 2023(15): 168-171+175 .
    18. 李宗艳,施雁,尹晓静. 老年患者术前焦虑非药物干预的研究进展. 现代临床护理. 2023(03): 78-84 .
    19. 包磊,朱丽群,舒芳芳,米元元,仲蕾媛,厉丽,顾苏,尚彬,曹雨晨,韩小云,唐为定. 成人择期手术术前焦虑非药物管理的最佳证据总结. 护士进修杂志. 2023(11): 1036-1042 .
    20. 薛云琴,郑伟熙,陈品英,官玉梅,陈春花. 集束化护理对经阴道腹腔镜手术患者的护理效果. 中国医药指南. 2023(18): 143-145 .
    21. 林秀珠. 术前针对性心理疏导对宫颈锥切术患者恐惧心理的影响. 西藏医药. 2023(03): 110-112 .
    22. 高佩,侯殿东,杜姝姝,汪小康,冯悦,高芳. 虚拟现实技术减轻病人术前焦虑研究进展. 护理研究. 2023(15): 2765-2770 .
    23. 梁碧芯,陈兴娅,何巧芳,周萍. 手术等待室舒心护理对腹腔镜胆囊切除患者术后心理应激的影响. 河北医药. 2023(17): 2703-2706 .
    24. 王玉鹏,胡小黎,张蓉,冯素文. 瘢痕子宫再次妊娠行剖宫产产妇安全感在信息需求与术前焦虑间的中介效应. 护理与康复. 2023(09): 12-16 .
    25. 林碧华,杨宝燕,陈碧霞. 基于智能“云随访”的护理路径在胆囊切除术患者中的应用效果. 护理实践与研究. 2022(19): 2939-2943 .
    26. 成兰,董玉燕,左莉红,沈海萍. 术前等待间手术患者焦虑与信息需求状况及其影响因素分析. 中华全科医学. 2022(10): 1797-1800 .
    27. 李中艳,陈爽,王倩. 局部浸润麻醉下自体肋软骨移植鼻尖成形术的围手术期护理. 中国医疗美容. 2022(10): 80-82+95 .
    28. 刘君红. 中医干预对外科手术前失眠及焦虑患者的影响观察. 黑龙江医药. 2022(06): 1423-1426 .

    Other cited types(6)

Catalog

    Article views (242) PDF downloads (9) Cited by(34)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return