Value of serum angiopoietin-like protein 2 and secreted frizzled-related protein 5 in predicting postoperative coronary slow flow in patients with acute coronary syndrome

Objective To explore the value of serum angiopoietin-like protein 2 (ANGPTL2) and secreted frizzled-related protein 5 (SFRP5) levels in predicting coronary slow flow (CSF) after percutaneous coronaryintervention (PCI) in patients with acute coronary syndrome (ACS).

Methods A total of 182 patients with ACS who underwent PCI were regarded as the research subjects. According to whether the patients developed CSF after PCI, they were grouped into CSF group (42 cases) and normal blood flow group (140 cases). Enzyme-linked immunosorbent assay (ELISA) was performed to detect the levels of serum ANGPTL2 and SFRP5 in ACS patients before PCI. Pearson correlation was performed to analyze the correlation between the levels of serum ANGPTL2 and SFRP5 in the CSF group before PCI. Multivariate Logistic regression was performed to analyze the risk factors of CSF after PCI in ACS patients; receiver operating characteristic (ROC) curve was performed to evaluate the predictive value of levels of serum ANGPTL2 and SFRP5 for CSF in patients with ACS after PCI.

Results The level of serum ANGPTL2 in the CSF group was (3.48±0.66) ng/mL, which was significantly higher than (2.80±0.51) ng/mL in the normal blood flow group (P < 0.05); the level of serum SFRP5 in the CSF group was (14.85±4.04) ng/mL, which was significantly lower than (22.12±4.69) ng/mL in the normal blood flow group (P < 0.05). There was a significant negative correlation between serum ANGPTL2 and SFRP5 before PCI in CSF group (r=-0.661, P < 0.001). High level of serum ANGPTL2 and low level of SFRP5 before PCI were risk factors for CSF in patients with ACS after PCI. The area under the ROC curve (AUC) of ANGPTL2 and SFRP5 in predicting CSF after PCI was significantly greater than that predicted by ANGPTL2 alone (Z=2.206, P=0.014) and by SFRP5 alone (Z=1.696, P=0.045).

Conclusion Serum ANGPTL2 and SFRP5 levels are the factors influencing the occurrence of CSF after PCI. The increased level of ANGPTL2 and decreased level of SFRP5 before and after PCI in patients with ACS are associated with the occurrence of CSF after PCI. The combined detection has predictive value for the occurrence of CSF after PCI in patients with ACS.