Objective To analyze the correlations of serum parathyroid hormone (PTH) and 25 hydroxyvitamin D25-(OH)-Dwith glycolipid metabolism in patients with type 2 diabetes mellitus complicated with carotid atherosclerosis (CAS).
Methods The clinical materials of 110 patients with type 2 diabetes mellitus from April 2019 to December 2021 were collected, and carotid ultrasound, glucose and lipid metabolism examination, and PTH and 25-(OH)-D detections were routinely performed after hospital admission. They were divided into simple type 2 diabetes group (n=51) and CAS group (n=59) according to the results of carotid artery intima-media thickness (CIMT) examination. The levels of PTH, 25-(OH)-D, blood glucose indexes fasting blood glucose (FBG), glycated hemoglobin (HbA1c)and blood lipids indexes total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C)were compared between the two groups, and the relationships of serum PTH and 25-(OH)-D with blood glucose and lipid metabolism were analyzed.
Results There were no significant differences in gender, age, body mass index and course of disease between the two groups (P > 0.05); the level of serum PTH in the CAS group was significantly higher than that in the simple type 2 diabetes group, while the level of 25-(OH)-D was significantly lower than that in the simple type 2 diabetes group (P < 0.05); the levels of FBG and HbA1c in the CAS group were significantly higher than those in the simple type 2 diabetes group (P < 0.05); levels of TC, TG and LDL-C in the CAS group were significantly higher than those in the simple type 2 diabetes group, while the HDL-C was significantly lower than that in the simple type 2 diabetes group (P < 0.05). The results of bivariate Pearson linear correlation test showed that serum PTH was positively correlated with FBG, HbA1c, TC and TG (P < 0.05), and negatively correlated with HDL-C in patients with type 2 diabetes complicated with CAS (P < 0.05). 25-(OH)-D was negatively correlated with HbA1c, TC and TG (P < 0.01), and positively correlated with HDL-C (P < 0.05).
Conclusion Serum PTH and 25-(OH)-D levels in type 2 diabetes mellitus patients with CAS are closely related to glucose and lipid metabolism.
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