GUO Jinzhi, TANG Shengjun, WANG Delu, QIAN Likang, ZHANG Yuanrui. Study on Helicobacter pylori serotypes, upper gastrointestinal diseases and effect of Helicobacter pylori eradication[J]. Journal of Clinical Medicine in Practice, 2022, 26(7): 128-131. DOI: 10.7619/jcmp.20220380
Citation: GUO Jinzhi, TANG Shengjun, WANG Delu, QIAN Likang, ZHANG Yuanrui. Study on Helicobacter pylori serotypes, upper gastrointestinal diseases and effect of Helicobacter pylori eradication[J]. Journal of Clinical Medicine in Practice, 2022, 26(7): 128-131. DOI: 10.7619/jcmp.20220380

Study on Helicobacter pylori serotypes, upper gastrointestinal diseases and effect of Helicobacter pylori eradication

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  • Received Date: February 07, 2022
  • Available Online: April 14, 2022
  • Published Date: April 14, 2022
  •     Objective   To observe Helicobacter pylori (Hp) serotypes, and compare eradication effects of different serological typing.
        Methods   A total of 267 patients with upper gastrointestinal symptoms were collected as study objects and were divided into chronic gastritis group(n=90), gastric polyps group(n=76) and peptic ulcer group(n=101). Venous blood was drawn from all patients, and expressions of Hp antibodies, including urease A(UreA), urease B (UreB), cytotoxin associated protein A (CagA) and vacuolating toxin associated protein A (VacA)in serum were detected. Hp infection rate and positive rates of UreA, UreB, CagA and VacA were compared in each group. Hp positive patients were treated with quadruple regimen, and Hp eradication rates of patients with different Hp types were compared.
        Results   The total Hp infection rate of 267 patients was 67.04%. The Hp infection rates of chronic gastritis group, gastric polyp group and peptic ulcer group were 61.11%, 51.32% and 84.16%, respectively. The Hp infection rate of the peptic ulcer group was higher than that of the chronic gastritis group and the gastric polyp group (P < 0.05). There was no significant difference in Hp infection rate between the chronic gastritis group and the gastric polyp group (P>0.05). The positive rates of UreA and VacA in the peptic ulcer group were higher than those in the chronic gastritis group and the gastric polyp group (P < 0.05). There was no significant difference in the positive rate of UreA and VacA between chronic gastritis group and gastric polyp group (P>0.05). The positive rate of UreB in the peptic ulcer group(93.07%) was higher than that in the chronic gastritis group (78.89%) and gastric polyp group(61.84%), and was higher in the chronic gastritis group than that in the gastric polyp group (P < 0.05). The positive rate of CagA in the peptic ulcer group(66.34%) was higher than 46.05% in the gastric polyp group (P < 0.05). There was no significant difference in CagA positive rate between the chronic gastritis group and gastric polyp group, between the chronic gastritis group and the peptic ulcer group (P>0.05). In the chronic gastritis group, gastric polyp group and peptic ulcer group, the infection rates of Hp type I were 83.64%, 87.18% and 77.65%, respectively, which were higher than that of Hp type Ⅱ. After quadruple regimen, the eradication rate of Hp type I was higher than that of type Ⅱ(86.99%versus 69.70%, P < 0.05).
        Conclusion   The infection rates of Hp typeⅠ in patients with chronic gastritis, gastric polyp and peptic ulcer are higher than those with Hp typeⅡ, the infection rate of Hp and positive rate of Hp antibody in patients with peptic ulcer are higher than those of chronic gastritis and gastric polyp, and the eradication rate of Hp type Ⅰ is higher than that of Hp type Ⅱ.
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