Objective To investigate the clinical value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) level in bronchopulmonary dysplasia (BPD) of premature infants.
Methods Eighty-one premature infants were selected and divided into BPD group (38 cases) and non-BPD group (43 cases) according to the diagnostic criteria of BPD.The BPD group was then divided into mild BPD group (20 cases) and moderate-severe BPD group (18 cases) according to relevant grading standards.The data of premature infants and mothers were collected, and the plasma NT-proBNP levels at 1day, 14 and 28 days after birth were analyzed.
Results The gestational age and birth weight of premature infants in the BPD group were significantly lower than those in the non-BPD group, and those in the moderate-severe BPD group were significantly lower than those in the mild BPD group (P < 0.05).The proportions of invasive ventilation duration ≥7 d and complicating with retinopathy of prematurity (ROP) in the BPD group were significantly higher than those in the non-BPD group, and those in the moderate-severe BPD group were higher than those in the mild BPD group (P < 0.05).The plasma NT-proBNP levels in the BPD group were significantly higher than those in the non-BPD group at 1 day, 14 and 28 days after birth, and those in the moderate-severe BPD group were significantly higher than that in the mild BPD group (P < 0.05).Receiver operating characteristic (ROC) curve analysis showed that the optimal cut-off values of plasma NT-proBNP level for predicting premature BPD at 1day, 14 and 28 days after birth were 4 233.5 pg/mL (sensitivity of 57.9%, specificity of 83.7%), 2 152.0 pg/mL (sensitivity of 89.5%, specificity of 79.1%) and 1 085.5 pg/mL (sensitivity of 94.7%, specificity of 79.1%), respectively.The optimal cut-off values of plasma NT-proBNPlevel at 1 day, 14 and 28 days after birth for predictingmoderate-severe BPD in premature infants were 4 918.0 pg/mL (sensitivity of 66.7%, specificity of 85.0%), 4 778.0 pg/mL (sensitivity of 100.0%, specificity of 90.0%) and 2 801.0 pg/mL (sensitivity of 88.9%, specificity of 100.0%), respectively.
Conclusion There was a certain correlation between NT-proBNP level and premature BPD, which could reflect the severity of the disease to a certain extent.Dynamic monitoring of plasma NT-proBNP level is conducive to the early diagnosis and risk stratification of premature BPD, and is conducive to early intervention and treatment as well as improvement of prognosis.
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