Efficacy of Jiawei Shengxian Decoction combined with conventional treatment in patients with ejection fraction reserved heart failure

Objective To observe effect of Jiawei Shengxian Decoction in patients with heart failure with preserved ejection fraction (HFpEF).

Methods A total of 60 HFpEF patients with qideficiency and blood stasis were selected as study objects, and were randomly divided into experimental group and control group, with 30 cases in each group.The control group was given conventional western medicine treatment, and the experimental group was orally administrated with Jiawei Shengxian Decoction on the basis of the control group.The treatment duration was 12 weeks.The scores of TCM symptoms, 6-minute walking test (6MWT) and changes of N-terminal brain natriuretic peptide (NT-ProBNP) were observed before and after treatment in two groups.

Results Scores of symptoms of chest tightness and panting, edema, palpitation, fatigue and laziness to speak, spontaneous sweating and shortness of breath between experimental group and control group (P < 0.05 or P < 0.01).The total score of TCM symptoms in two groups after treatment was reduced, but the total score of TCM symptoms in the experimental group decreased more significantly (P < 0.01).After treatment, 6MWT of the two groups was significantly increased, and 6MWT of the experimental group was significantly higher than that of the control group (P < 0.05 or P < 0.01).After treatment, NT-ProBNP in two groups was significantly decreased, and the decrease of NT-ProBNP in the experimental group was greater than that in the control group (P < 0.05 or P < 0.01).

Conclusion Jiawei Shengxian Decoction has better therapeutic effect in HFpEF patients, it can adjust the functions of viscera, qi and blood, effectively improve the clinical symptoms and heart function of patients with HFpEF, and is an effective treatment.