Research progress on roles of blood biomarkers in etiological classification of ischemic stroke

YOU Jing; HE Miao; ZHOU Feng; LI Weirong

doi:10.7619/jcmp.20214524

Journal of Clinical Medicine in Practice > 2022 > 26(6): 118-122. > DOI: 10.7619/jcmp.20214524

YOU Jing, HE Miao, ZHOU Feng, LI Weirong. Research progress on roles of blood biomarkers in etiological classification of ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2022, 26(6): 118-122. DOI: 10.7619/jcmp.20214524

Citation:

PDF (644 KB)

Research progress on roles of blood biomarkers in etiological classification of ischemic stroke

1.
Department of Neurology, the Ninth Clinical Medical College Affiliated to Shanxi Medical University, Taiyuan, Shanxi, 030009
2.
Taiyuan Psychiatric Hospital of Shanxi Province, Taiyuan, Shanxi, 030045

More Information

Received Date: November 16, 2021
Available Online: April 08, 2022
Published Date: March 27, 2022

Graphical Abstract

Abstract

Abstract

At present, blood biomarkers such as C-reactive protein and neutrophil-to-lymphocyte ratio, have been proved to have predictive roles in early etiological classification of ischemic stroke. This article reviewed the related blood biomarkers in different subtypes of ischemic stroke in order to provide diagnostic basis for the classification of different subtypes of ischemic stroke.

FullText(HTML)

References (32)

References

[1]	WANG Y J, LI Z X, GU H Q, et al. China stroke statistics 2019: a report from the national center for healthcare quality management in neurological diseases, China national clinical research center for neurological diseases, the Chinese stroke association, national center for chronic and non-communicable disease control and prevention, Chinese center for disease control and prevention and institute for global neuroscience and stroke collaborations[J]. Stroke Vasc Neurol, 2020, 5(3): 211-239. doi: 10.1136/svn-2020-000457
[2]	KIM S J, MOON G J, BANG O Y. Biomarkers for stroke[J]. J Stroke, 2013, 15(1): 27-37. doi: 10.5853/jos.2013.15.1.27
[3]	MAKRIS K, HALIASSOS A, CHONDROGIANNI M, et al. Blood biomarkers in ischemic stroke: potential role and challenges in clinical practice and research[J]. Crit Rev Clin Lab Sci, 2018, 55(5): 294-328. doi: 10.1080/10408363.2018.1461190
[4]	PICCARDI B, GIRALT D, BUSTAMANTE A, et al. Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis[J]. Biomarkers, 2017, 22(3/4): 200-209.
[5]	TUTTOLOMONDO A, DI RAIMONDO D, PECORARO R, et al. Inflammation in ischemic stroke subtypes[J]. Curr Pharm Des, 2012, 18(28): 4289-4310. doi: 10.2174/138161212802481200
[6]	ZENG L L, HE X S, LIU J R, et al. Differences of circulating inflammatory markers between large and small vessel disease in patients with acute ischemic stroke[J]. Int J Med Sci, 2013, 10(10): 1399-1405. doi: 10.7150/ijms.6652
[7]	SUWANWELA N C, CHUTINET A, PHANTHUMCHINDA K. Inflammatory markers and conventional atherosclerotic risk factors in acute ischemic stroke: comparative study between vascular disease subtypes[J]. J Med Assoc Thai, 2006, 89(12): 2021-2027.
[8]	LIU L B, LI M, ZHUO W Y, et al. The role of hs-CRP, D-dimer and fibrinogen in differentiating etiological subtypes of ischemic stroke[J]. PLoS One, 2015, 10(2): e0118301. doi: 10.1371/journal.pone.0118301
[9]	PELLEGRINO P L, BRUNETTI N D, DE GENNARO L, et al. Inflammatory activation in an unselected population of subjects with atrial fibrillation: links with structural heart disease, atrial remodeling and recent onset[J]. Intern Emerg Med, 2013, 8(2): 123-128. doi: 10.1007/s11739-011-0557-z
[10]	LOK U, GULACTI U. The predictive effect of the neutrophil-to-lymphocyte ratio (NLR) on the mortality of acute ischemic stroke and its subtypes: a retrospective cross-sectional study[J]. Eurasian J Emerg Med, 2016, 15(2): 69-72. doi: 10.5152/eajem.2016.39974
[11]	TOKGOZ S, KAYRAK M, AKPINAR Z, et al. Neutrophil lymphocyte ratio as a predictor of stroke[J]. J Stroke Cerebrovasc Dis, 2013, 22(7): 1169-1174. doi: 10.1016/j.jstrokecerebrovasdis.2013.01.011
[12]	DOMAÇ F, ÜLKER M, KARACI R, et al. The relation between neutrophil-lymphocyte ratio and etiologic subtypes in acute ischaemic stroke[J]. Haydarpaşa Numune Med J, 2021, 61(2): 145.
[13]	QUN S, HU F Y, WANG G P, et al. Serum beta2-microglobulin levels are highly associated with the risk of acute ischemic stroke[J]. Sci Rep, 2019, 9(1): 6883. doi: 10.1038/s41598-019-43370-9
[14]	CUI N, HU M, KHALIL R A. Biochemical and biological attributes of matrix metalloproteinases[J]. Prog Mol Biol Transl Sci, 2017, 147: 1-73.
[15]	ALHAZMI H, BANI-SADR A, BOCHATON T, et al. Large vessel cardioembolic stroke and embolic stroke of undetermined source share a common profile of matrix metalloproteinase-9 level and susceptibility vessel sign length[J]. Eur J Neurol, 2021, 28(6): 1977-1983. doi: 10.1111/ene.14806
[16]	CÁRCEL-MÁRQUEZ J, CULLELL N, MUIÑO E, et al. Causal effect of MMP-1 (matrix metalloproteinase-1), MMP-8, and MMP-12 levels on ischemic stroke: a Mendelian randomization study[J]. Stroke, 2021, 52(7): e316-e320.
[17]	DELGADO P, CHACÓN P, PENALBA A, et al. Lipoprotein-associated phospholipase A(2) activity is associated with large-artery atherosclerotic etiology and recurrent stroke in TIA patients[J]. Cerebrovasc Dis, 2012, 33(2): 150-158. doi: 10.1159/000334193
[18]	HU G F, LIU D P, TONG H Y, et al. Lipoprotein-associated phospholipase A2 activity and mass as independent risk factor of stroke: a meta-analysis[J]. Biomed Res Int, 2019, 2019: 8642784.
[19]	WISEMAN S, MARLBOROUGH F, DOUBAL F, et al. Blood markers of coagulation, fibrinolysis, endothelial dysfunction and inflammation in lacunar stroke versus non-lacunar stroke and non-stroke: systematic review and meta-analysis[J]. Cerebrovasc Dis, 2014, 37(1): 64-75. doi: 10.1159/000356789
[20]	ZI W J, SHUAI J. Plasma D-dimer levels are associated with stroke subtypes and infarction volume in patients with acute ischemic stroke[J]. PLoS One, 2014, 9(1): e86465. doi: 10.1371/journal.pone.0086465
[21]	KIM Y D, SONG D, NAM H S, et al. D-dimer for prediction of long-term outcome in cryptogenic stroke patients with patent foramen ovale[J]. Thromb Haemost, 2015, 114(3): 614-622.
[22]	KIM S J, PARK J H, LEE M J, et al. Clues to occult cancer in patients with ischemic stroke[J]. PLoS One, 2012, 7(9): e44959. doi: 10.1371/journal.pone.0044959
[23]	YUAN B B, LUO G G, GAO J X, et al. Variance of serum lipid levels in stroke subtypes[J]. Clin Lab, 2015, 61(10): 1509-1514.
[24]	KIM B S, JUNG H S, BANG O Y, et al. Elevated serum lipoprotein(a) as a potential predictor for combined intracranial and extracranial artery Stenosis in patients with ischemic stroke[J]. Atherosclerosis, 2010, 212(2): 682-688. doi: 10.1016/j.atherosclerosis.2010.07.007
[25]	HINDY G, ENGSTRÖM G, LARSSON S C, et al. Role of blood lipids in the development of ischemic stroke and its subtypes: a Mendelian randomization study[J]. Stroke, 2018, 49(4): 820-827. doi: 10.1161/STROKEAHA.117.019653
[26]	KAYRAN Y, YAYLA V, ÇABALAR M, et al. LDL subclasses in ischemic stroke: a risk factor[J]. Noro Psikiyatr Ars, 2019, 56(1): 13-17.
[27]	LLOMBART V, ANTOLIN-FONTES A, BUSTAMANTE A, et al. B-type natriuretic peptides help in cardioembolic stroke diagnosis: pooled data meta-analysis[J]. Stroke, 2015, 46(5): 1187-1195. doi: 10.1161/STROKEAHA.114.008311
[28]	KAWASE S, KOWA H, SUTO Y, et al. Plasma brain natriuretic peptide is a marker of prognostic functional outcome in non-cardioembolic infarction[J]. J Stroke Cerebrovasc Dis, 2015, 24(10): 2285-2290. doi: 10.1016/j.jstrokecerebrovasdis.2015.06.006
[29]	WU Z X, ZHAO M M, HE M F, et al. Validation of the use of B-type natriuretic peptide point-of-care test platform in preliminary recognition of cardioembolic stroke patients in the ED[J]. Am J Emerg Med, 2015, 33(4): 521-526. doi: 10.1016/j.ajem.2015.01.013
[30]	BAI J X, SUN H C, XIE L, et al. Detection of cardioembolic stroke with B-type natriuretic peptide or N-terminal pro-BNP: a comparative diagnostic meta-analysis[J]. Int J Neurosci, 2018, 128(11): 1100-1108. doi: 10.1080/00207454.2017.1408612
[31]	ZHU Z, TANG W J, GE L, et al. The value of plasma fibrillin-1 level in patients with spontaneous cerebral artery dissection[J]. Neurology, 2018, 90(9): e732-e737. doi: 10.1212/WNL.0000000000005027
[32]	RÜCKER V, HEUSCHMANN P U, O'FLAHERTY M, et al. Twenty-year time trends in long-term case-fatality and recurrence rates after ischemic stroke stratified by etiology[J]. Stroke, 2020, 51(9): 2778-2785. doi: 10.1161/STROKEAHA.120.029972

[1]	YAO Binbin, SHEN Yan, YANG Hongli, FENG Sujuan, HUANG Huaxing, ZHU Xueling, SHEN Lianglan. Impact of serum cystatin C and hypersensitivity C-reactive protein on the 3-year survival of patients undergoing maintenance hemodialysis[J]. Journal of Clinical Medicine in Practice, 2024, 28(18): 68-75, 80. DOI: 10.7619/jcmp.20240283
[2]	PENG Shunxian, TAO Hua, CHEN Xiaofeng, PENG Jifang, JIANG Shudi. Application value of C-reactive protein to albumin ratio combined with grip strength and serum prealbumin in patients with esophageal cancer[J]. Journal of Clinical Medicine in Practice, 2024, 28(17): 15-19, 26. DOI: 10.7619/jcmp.20242187
[3]	REN Xiangli, REN Xiangjie, MA Xuejing, LIU Zhaowei, BAI Yu. Value of serum hemoglobin scavenger receptor soluble CD163 combined with neutrophil to lymphocyte ratio in predicting prognosis of patients with stroke-related pneumonia[J]. Journal of Clinical Medicine in Practice, 2022, 26(2): 18-22. DOI: 10.7619/jcmp.20213068
[4]	BAO Yingshi, LIU Jianhong, DU Huaping, JIA Xianjun. Value of C-reactive protein combined with neutrophil to lymphocyte ratio in predicting post-stroke depression of patients with ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2021, 25(22): 59-62. DOI: 10.7619/jcmp.20213865
[5]	QIU Yuan, LI Li, ZENG Laixing. Changes of C reactive protein and serum procalcitoninin patients with severe acute pancreatitis[J]. Journal of Clinical Medicine in Practice, 2019, 23(12): 62-64. DOI: 10.7619/jcmp.201912018
[6]	LIU Li, LIU Mingxin, NIU Shihui, LU Zejun, WANG Nana, ZHANG Ling. Effect of irbesartan combined with atorvastatin on C reactive protein and cystatin C of patients with diabetic nephropathy[J]. Journal of Clinical Medicine in Practice, 2017, (21): 33-35. DOI: 10.7619/jcmp.201721009
[7]	LU Yunnan, HUA Ye, FENG Zhiqiang, MA Tao, HE Peicheng, WU Shuangshuang, XU Hong. Effect of edaravone combined with statins on serum homocysteine, C-reactive protein and lipid levels in patients with ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2017, (19): 27-30. DOI: 10.7619/jcmp.201719008
[8]	ZHANG Shihui, ZHANG Yan, TANG Xi. Effects of hemodialysis combined with hemoperfusion on expression of β2-microglobulin and high-sensitivity C-reactive protein in patients with uremia[J]. Journal of Clinical Medicine in Practice, 2017, (5): 65-67. DOI: 10.7619/jcmp.201705018
[9]	BAI Bin, YUAN Anlong, KOU Jiguang. Application of fecal calprotectin and serum C-reactive protein detections in evaluation of activity determination of ulcerative colitis[J]. Journal of Clinical Medicine in Practice, 2015, (1): 56-58. DOI: 10.7619/jcmp.201501017
[10]	XU Bin, FAN Zhigang, YANG Yun, XU Zongxian. Application of serum procalcitonin and C-reactive protein detections in the diagnosis of neonatal severe infectious disease[J]. Journal of Clinical Medicine in Practice, 2014, (24): 50-52. DOI: 10.7619/jcmp.201424015

Cited By

Get Citation

PDF

XML

Article views (252) PDF downloads (27)

Turn off MathJax

Article Contents

Abstract

References

Research progress on roles of blood biomarkers in etiological classification of ischemic stroke

Abstract

References

Related Articles

Catalog

Research progress on roles of blood biomarkers in etiological classification of ischemic stroke

Abstract

References

Related Articles

Catalog

Export File

Citation

Format

Content