Effect of Fuzheng Jiedu Decoction on clinical efficacy in patients with sepsis

  Objective  To explore the effect of Fuzheng Jiedu Decoction on clinical effects in patients with sepsis.

  Methods  A total of 92 patients with sepsis were selected as research objects, and randomly divided into two groups, with 46 cases in each group. The control group was treated with conventional western medicine, while the test group was treated with conventional therapy and Fuzheng Jiedu Decoction in combination. The therapeutic effects, Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE) score, levels of serum C-reactive protein (CRP), interleukin-6 (IL-6), and serum procalcitonin (PCT) as well as levels of hemodynamic indexes in patients with sepsis of two groups were compared and analyzed.

  Results  Before treatment, there were no significant differences in APACHE Ⅱ score, levels of serum CRP, IL-6, PCT and hemodynamic indexes between the two groups (P>0.05). After treatment, the APACHE Ⅱ score, serum CRP, IL-6 and PCT levels decreased, thoracic fluid level (TFC) and systemic vascular resistance index (SVRI) decreased, and the mean arterial pressure (MAP) and cardiac index (CI) increased(P < 0.05). The APACHE Ⅱ score, levels of CRP, IL-6, PCT, TFC and SVRI in the test group were lower than those in the control group, and the levels of MAP and CI were higher than those in the control group(P < 0.05). Compared with the control group, the total effective rate of the test group was higher and the incidence of adverse reactions was lower, there were significant differences between the two groups (P < 0.05).

  Conclusion  Fuzheng Jiedu Decoction has good effects for patients with sepsis, and it can improve the serum levels and hemodynamic indexes of the patients, and reduce the incidence of adverse reactions.