Efficacy of continuous veno-venous hemofiltration in treatment of chronic renal failure patients complicated with cerebral hemorrhage

  Objective  To explore the effects of continuous veno-venous hemofiltration (CVVH) on neurological function, renal function and prognosis of chronic renal failure (CRF) patients complicated with cerebral hemorrhage.

  Methods  A total of 90 CRF patients complicated with cerebral hemorrhage were analyzed retrospectively, and they were divided into observation group and control group, with 45 cases in each group. The observation group was treated with CVVH for blood purification, and the control group was treated with intermittent hemodialysis (IHD) for blood purification. The National Institute of Health Stroke Scale (NIHSS) and Mini-mental State Examination (MMSE) were used to evaluate the neurological deficit status and mental intelligence status of the patients before treatment and 14 days after treatment; the renal function, blood urea nitrogen (BUN) and serum creatinine (Scr) were compared between the two groups before treatment and 14 days after treatment; the incidence of complications was compared between the two groups.

  Results  After 14 days of treatment, the NIHSS score decreased significantly and MMSE score increased significantly in both groups (P < 0.05), and the NIHSS score of the observation group was significantly lower than that of the control group (P < 0.05), while the MMSE score of the observation group was significantly higher than that of the control group (P < 0.05); after 14 days of treatment, the BUN and Scr levels decreased significantly in both groups, and the BUN and Scr levels of the observation group were significantly lower than those of the control group (P < 0.05); the incidence of acute heart failure was 15.56%(7/45) in the observation group, which was significantly lower than 37.78%(17/45) in the control group (P < 0.05); the incidence of hospital acquired pneumonia in the observation group was 24.44%(11/45), which was significantly lower than 44.44%(20/45) in the control group(P < 0.05).

  Conclusion  CVVH can effectively treat the CRF patients complicated with cerebral hemorrhage, which can effectively improve the neurological function of patients, promote the recovery of renal function and reduce the incidence of complications.