Effects of different doses of vitamin K₁ on acute bromadiolone poisoning

  Objective  To investigate the effects of different doses of vitamin K₁ in the improvement of coagulation function in patients with acute bromadiolone poisoning.

  Methods  A total of 32 patients with oral bromodiolone poisoning admitted to the department of emergency medicine were selected as study objects, and were divided into observation group(17 cases) and control group (15 cases) according to different dosage of vitamin K₁. The control group was given intravenous infusion of vitamin K₁ for 20 mg/d, conventional treatment such as gastric lavage, liver protection and fluid rehydration were performed, while the observation group conducted intravenous infusion of vitamin K₁ for 40 mg/d, and routine treatment was the same as the control group. Coagulation function indexes before and after treatment and hospital stay were recorded.

  Results  After treatment, the clinical symptoms of all patients in the two groups were significantly improved. The coagulation indexes such as prothrombin time (PT), activated partial thrombin time (APTT) and international standardized ratio (INR) of the control group and the observation group were significantly improved after treatment compared with before treatment (P < 0.05), and the indexes of coagulation function in the observation group improved better than that of the control group, but there were no statistical significances between the two groups after treatment (P>0.05). The coagulation indexes of patients with time < 48 h from poisoning to treatment were better than those with time ≥48 h from poisoning to treatment, and the difference was statistically significant (P < 0.05). The length of hospitalization in the observation group was (5.69±1.85) d, which was shorter than (5.94±1.56) d in the control group, but the difference was not statistically significant (P>0.05).

  Conclusion  Vitamin K₁ can effectively improve the coagulation dysfunction caused by bromadiolone poisoning. Higher dose of vitamin K₁ can promote the recovery of coagulation function and accelerate the improvement of clinical symptoms.