Clinical characteristics and risk factors of patients with rheumatoid arthritis and positive thyroid peroxidase antibody

ZHENG Wenjuan; TANG Yu; SHI Wei; JIANG Yu; CHEN Di; FEI Xiaoming

doi:10.7619/jcmp.20213399

Journal of Clinical Medicine in Practice > 2022 > 26(1): 99-102. > DOI: 10.7619/jcmp.20213399

ZHENG Wenjuan, TANG Yu, SHI Wei, JIANG Yu, CHEN Di, FEI Xiaoming. Clinical characteristics and risk factors of patients with rheumatoid arthritis and positive thyroid peroxidase antibody[J]. Journal of Clinical Medicine in Practice, 2022, 26(1): 99-102. DOI: 10.7619/jcmp.20213399

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Clinical characteristics and risk factors of patients with rheumatoid arthritis and positive thyroid peroxidase antibody

1.
Department of Rheumatology and Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001
2.
Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001

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Received Date: August 23, 2021
Available Online: January 09, 2022
Published Date: January 14, 2022

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Abstract

Abstract

Objective To investigate clinical characteristics of patients with rheumatoid arthritis (RA) and positive thyroid peroxidase antibody (TPOAb), and to analyze the risk factors affecting the level of TPOAb.
Methods A total of 191 RA patients were selected as study objects and were divided into TPOAb negative group (TPOAb ≤ 34 IU/mL) and TPOAb positive group (TPOAb >34 IU/mL). The differences of clinical data, laboratory indexes and immunological indexes between the two groups were compared, and the risk factors of TPOAb level were determined by multivariate Logistic regression analysis.
Results Age and interleukin-10 (IL-10) in the TPOAb positive group were lower than those in the TPOAb negative group (P < 0.05), the level of interleukin-17 (IL-17) and tumor necrosis factor-α (TNF-α) in the TPOAb positive group were higher than those in the TPOAb negative group (P < 0.05). Multivariate Logistic regression analysis showed the higher level of IL-17 (OR=1.395, 95%CI, 1.005 to 1.937, P=0.047) and higher level of TNF-α (OR=1.051, 95%CI, 1.013 to 1.090, P=0.008)and lower level of IL-10 (OR=0.795, 95%CI, 0.652 to 0.968, P=0.022) were independent influencing factors for positive TPOAb.
Conclusion In RA patients, the positive rate of TPOAb is 14.7%(correlated with to age). High levels of IL-17 and TNF-α and low level of IL-10 are high risk factors of TPOAb.
- rheumatoid arthritis,
- thyroid peroxidase antibody,
- tumor necrosis factor-α,
- interleukin-10,
- interleukin-17

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Clinical characteristics and risk factors of patients with rheumatoid arthritis and positive thyroid peroxidase antibody

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