Research progress on influence of clinical drugs on antitumor effect of immune checkpoint inhibitors

Although immune checkpoint inhibitors (ICI) can significantly improve the clinical prognosis of patients with advanced solid tumors, a considerable number of patients still can't benefit from ICI treatment. In clinical practice, lots of drugs such as antibiotics, glucocorticoids, proton pump inhibitors and β receptor blockers can affect the antitumor effect of ICI drugs through different mechanisms. Antibiotics and proton pump inhibitors may inhibit the therapeutic effect of ICI by affecting intestinal flora, and β receptor blockers may enhance tumor sensitivity to ICI therapy by inhibiting β adrenoceptor signaling pathway. The effect of glucocorticoid on the therapeutic effect of ICI may depend on its indications, such as tumor/non-tumor related symptoms and immunotherapy related side effects. This study reviewed the related researches on the above clinical drugs in ICI treatment, in order to provide a theoretical basis for optimizing the individualized treatment strategy of ICI in patients with advanced tumors.