Changes of serum adropin, platelet activating factor and glial fibrillary acidic protein levels in patients with coronary heart disease complicating depression and their significance

LIAO Dongsheng; A Huaihong; LI Shaohua; GAO Chunyuan; SHEN Jun; WANG Hongjun

doi:10.7619/jcmp.20212667

Journal of Clinical Medicine in Practice > 2021 > 25(24): 74-77, 82. > DOI: 10.7619/jcmp.20212667

LIAO Dongsheng, A Huaihong, LI Shaohua, GAO Chunyuan, SHEN Jun, WANG Hongjun. Changes of serum adropin, platelet activating factor and glial fibrillary acidic protein levels in patients with coronary heart disease complicating depression and their significance[J]. Journal of Clinical Medicine in Practice, 2021, 25(24): 74-77, 82. DOI: 10.7619/jcmp.20212667

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Changes of serum adropin, platelet activating factor and glial fibrillary acidic protein levels in patients with coronary heart disease complicating depression and their significance

1.
Psychiatry Department, the Third People's Hospital of Qinghai Province, Xining, Qinghai, 810007
2.
Department of Psychosomatic Medicine, the Third People's Hospital of Qinghai Province, Xining, Qinghai, 810007
3.
Department of Psychiatry, the Fifth Hospital of Wuhan City of Hubei Province, Wuhan, Hubei, 430000

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Received Date: June 28, 2021
Available Online: January 04, 2022
Published Date: December 27, 2021

Graphical Abstract

Abstract

Abstract

Objective To investigate the changes and correlations of serum adropin, platelet activating factor (PAF) and glial fibrillary acidic protein (GFAP) in patients with coronary heart disease (CHD) and depression.
Methods A total of 163 patients with CHD were selected as objects, the patients were divided into depression group (98 cases including 47 cases of mild depression, 31 cases of moderate depression and 20 cases of moderate depression, HAMD scored ≥ 18) and non-depression group (65 cases, HAMD scored < 18) according to Hamilton Depression Scale (HAMD) score. The levels of serum adropin, PAF and GFAP were detected by enzyme-linked immunosorbent assay (ELISA). Pearson method was used to analyze the correlations between serum adropin and PAF, GFAP levels in CHD patients with depression. Logistic regression analysis was used to analyze the influencing factors of depression in CHD patients.
Results The levels of fasting blood glucose, PAF and GFAP in the depression group were higher than those in non-depression group, while the level of serum adropin was lower than that in the non-depressive group (P < 0.05). In the depression group, serum adropin levels in mild, moderate and severe depression patients gradually decreased, while PAF and GFAP levels gradually increased (P < 0.05). Pearson correlation analysis showed that serum adropin level was negatively correlated with PAF and GFAP levels in CHD patients with depression (r=-0.665, -0.643, P < 0.001); multivariate Logistic regression analysis showed that serum adropin level < 49.36 pg/mL, PAF level ≥ 124.47 pg/mL, GFAP level ≥ 12.79 ng/mL were the independent influencing factors of depression in CHD patients (P < 0.05).
Conclusion With the aggravation of depression in patients with CHD, serum adropin level is decreased and levels of PAF and GFAP are increased. Serum adropin level is negatively correlated with PAF and GFAP levels, and all of them are independent influencing factors of depression in CHD patients.
- coronary heart disease,
- depression,
- adropin,
- platelet activating factor,
- glial fibrillary acidic protein,
- correlation

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References

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Changes of serum adropin, platelet activating factor and glial fibrillary acidic protein levels in patients with coronary heart disease complicating depression and their significance