Correlation between serum N-terminal mid-fragment of osteocalcin and index of glucose metabolism after fracture

HUANG Jianyin; YANG Yanping; HUANG Guandong; YANG Kaichao; ZHONG Weixi; FENG Qiming

doi:10.7619/jcmp.20212356

Journal of Clinical Medicine in Practice > 2022 > 26(1): 80-84. > DOI: 10.7619/jcmp.20212356

HUANG Jianyin, YANG Yanping, HUANG Guandong, YANG Kaichao, ZHONG Weixi, FENG Qiming. Correlation between serum N-terminal mid-fragment of osteocalcin and index of glucose metabolism after fracture[J]. Journal of Clinical Medicine in Practice, 2022, 26(1): 80-84. DOI: 10.7619/jcmp.20212356

Citation:

PDF (807 KB)

Correlation between serum N-terminal mid-fragment of osteocalcin and index of glucose metabolism after fracture

Department of Emergency Medicine, the Sixth People′s Hospital Affiliated to Shanghai Jiaotong University, Shanghai, 200233

More Information

Received Date: June 06, 2021
Available Online: January 19, 2022
Published Date: January 14, 2022

Graphical Abstract

Abstract

Abstract

Objective To investigate the relationships between serum N-terminal mid-fragment of osteocalcin (N-MID OC) and hemoglobin A1c(HbA1c), fasting plasma glucose(FPG), fasting insulin (FINS) and C-peptide (C-P).
Methods A total of 196 male patients with single closed fracture were included in fracture group and 64 healthy men in healthy control group based on a retrospective study method, and the general data and biochemical indexes of the two groups were compared. The fracture patients were divided into four subgroups according to N-MID OC quartile, and the levels of HbA1c, FPG, FINS and C-P in four groups were compared. The correlations of serum N-Mid OC level with glucose metabolism and biochemical indexes were analyzed.
Results There were no differences in age, body mass index, serum creatinine and HbA1c between the fracture group and the healthy control group (P>0.05). Leukocyte, alanine aminotransferase, aspartate aminotransferase, FPG, FINS, C-P in the fracture group were higher than those in the healthy control group, while platelets, hemoglobin, calcium ions, the levels of 25-hydroxyvitamin D₃ and N-MID OC levels were lower than those of the healthy control group (P < 0.05). There were significant differences in age, platelets, FPG, and N-MID OC in the subgroups (P < 0.05). Correlation analysis showed that serum N-MID OC was negatively correlated with age (r=-0.280, P < 0.001), HbA1c(r=-0.081, P=0.011) and FPG(r=-0.196, P=0.006). After adjusting for age factor, multiple linear regression analysis showed that FPG was an independent factor affecting serum N-MID OC of patients with single closed fracture(β=-0.147, P < 0.001, 95%CI, -0.663 to -0.023).
Conclusion There is a correlation between glucose metabolism and serum N-MID OC after fracture, which may be a factor affecting bone metabolism.
- fracture,
- N-terminal mid-fragment of osteocalcin,
- hemoglobin A1c,
- glucose,
- insulin,
- C-peptid

FullText(HTML)

References (23)

References

[1]	PICKE A K, CAMPBELL G, NAPOLI N, et al. Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties[J]. Endocr Connect, 2019, 8(3): R55-R70. doi: 10.1530/EC-18-0456
[2]	FERRON M, WEI J, YOSHIZAWA T, et al. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism[J]. Cell, 2010, 142(2): 296-308. doi: 10.1016/j.cell.2010.06.003
[3]	WEI J, FERRON M, CLARKE C J, et al. Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation[J]. J Clin Invest, 2014, 124(4): 1-13.
[4]	MOSER S C, VAN DER EERDEN B C J. Osteocalcin-A versatile bone-derived hormone[J]. Front Endocrinol: Lausanne, 2018, 9: 794.
[5]	NAGASUE K, INABA M, OKUNO S, et al. Serum N-terminal midfragment vs. intact osteocalcin immunoradiometric assay as markers for bone turnover and bone loss in hemodialysis patients[J]. Biomed Pharmacother, 2003, 57(2): 98-104. doi: 10.1016/S0753-3322(02)00344-X
[6]	TANIGUCHI T, MATSUMOTO T, SHINDO H. Changes of serum levels of osteocalcin, alkaline phosphatase, IGF-I and IGF-binding protein-3 during fracture healing[J]. Injury, 2003, 34(7): 477-479. doi: 10.1016/S0020-1383(02)00380-7
[7]	JESCHKE M G, BOEHNING D. Endoplasmic Reticulum stress and insulin resistance post-trauma: similarities to type 2 diabetes[J]. J Cell Mol Med, 2012, 16(3): 437-444. doi: 10.1111/j.1582-4934.2011.01405.x
[8]	CHEN Y, ZHAO Q, DU G, et al. Association between serum osteocalcin and glucose/lipid metabolism in Chinese Han and Uygur populations with type 2 diabetes mellitus in Xinjiang: two cross-sectional studies[J]. Lipids Health Dis, 2017, 16(1): 139. doi: 10.1186/s12944-017-0512-8
[9]	DU J, PAN X, LU Z, et al. Serum osteocalcin levels are inversely associated with the presence of nonalcoholic fatty liver disease in patients with coronary artery disease[J]. Int J Clin Exp Med, 2015, 8(11): 21435-21441.
[10]	LUO Y Q, MA X J, HAO Y P, et al. Inverse relationship between serum osteocalcin levels and nonalcoholic fatty liver disease in postmenopausal Chinese women with normal blood glucose levels[J]. Acta Pharmacol Sin, 2015, 36(12): 1497-1502. doi: 10.1038/aps.2015.81
[11]	TAKASHI Y, KOGA M, MATSUZAWA Y, et al. Undercarboxylated osteocalcin can predict insulin secretion ability in type 2 diabetes[J]. J Diabetes Investig, 2017, 8(4): 471-474. doi: 10.1111/jdi.12601
[12]	YANG Y P, ZHONG W X, HUANG J Y, et al. Association of serum osteocalcin levels with glucose metabolism in trauma patients[J]. Medicine, 2020, 99(36): e21901. doi: 10.1097/MD.0000000000021901
[13]	BERGER M, ORTEGO A. Calculated decisions: injury severity score (ISS)[J]. Pediatr Emerg Med Pract, 2019, 16(5): CD1-CD2.
[14]	BHADRICHA H, KHATKHATAY M I, DESAI M. Development of an in house ELISA for human intact osteocalcin and its utility in diagnosis and management of osteoporosis[J]. Clin Chim Acta, 2019, 489: 117-123. doi: 10.1016/j.cca.2018.12.007
[15]	AGUSTINA H, ASYIFA I, AZIZ A, et al. The role of osteocalcin and alkaline phosphatase immunohistochemistry in osteosarcoma diagnosis[J]. Pathol Res Int, 2018, 2018: 6346409.
[16]	LEE N K, SOWA H, HINOI E, et al. Endocrine regulation of energy metabolism by the skeleton[J]. Cell, 2007, 130(3): 456-469. doi: 10.1016/j.cell.2007.05.047
[17]	GIUDICI K V, KINDLER J M, MARTIN B R, et al. Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States[J]. Nutr Metab: Lond, 2017, 14: 25. doi: 10.1186/s12986-017-0171-9
[18]	HU W W, KE Y H, HE J W, et al. Serum osteocalcin levels are inversely associated with plasma glucose and body mass index in healthy Chinese women[J]. Acta Pharmacol Sin, 2014, 35(12): 1521-1526. doi: 10.1038/aps.2014.92
[19]	LI L, MESSINA J L. Acute insulin resistance following injury[J]. Trends Endocrinol Metab, 2009, 20(9): 429-435. doi: 10.1016/j.tem.2009.06.004
[20]	PARKER L, LIN X, GARNHAM A, et al. Glucocorticoid-induced insulin resistance in men is associated with suppressed undercarboxylated osteocalcin[J]. J Bone Miner Res, 2019, 34(1): 49-58. doi: 10.1002/jbmr.3574
[21]	BILOTTA F L, ARCIDIACONO B, MESSINEO S, et al. Insulin and osteocalcin: further evidence for a mutual cross-talk[J]. Endocrine, 2018, 59(3): 622-632. doi: 10.1007/s12020-017-1396-0
[22]	LEVINGER I, JERUMS G, STEPTO N K, et al. The effect of acute exercise on undercarboxylated osteocalcin and insulin sensitivity in obese men[J]. J Bone Miner Res, 2014, 29(12): 2571-2576. doi: 10.1002/jbmr.2285
[23]	STARUP-LINDE J, WESTBERG-RASMUSSEN S, LYKKEBOE S, et al. Glucose tolerance tests and osteocalcin responses in healthy people[J]. Front Endocrinol: Lausanne, 2018, 9: 356. doi: 10.3389/fendo.2018.00356

Cited By

Get Citation

PDF

XML

Article views (278) PDF downloads (7)

Turn off MathJax

Article Contents

Abstract

References

Correlation between serum N-terminal mid-fragment of osteocalcin and index of glucose metabolism after fracture

Abstract

References

Catalog

Export File

Citation

Format

Content