Efficacy of proton pump inhibitors plus ranitidine in treating patients with peptic ulcers and its effects on levels of glutathione peroxidase and lipid peroxides

  Objective  To observe the effects of proton pump inhibitors combined with ranitidine in treating patients with peptic ulcers and its effects on the levels of glutathione peroxidase (GSH Px) and lipid peroxides (LPO).

  Methods  A total of 120 patients with peptic ulcer were selected and randomly divided into ranitidine group and combined treatment group, with 60 cases in each group. Ranitidine group was treated with ranitidine, and combined treatment group was treated proton pump inhibitor combined with ranitidine. H⁺-K⁺-ATPase activity and gastric pH level, GSH-Px, LPO level, interleukin (IL-17), IL-6 and IL-8 levels of patients in the two groups were detected. The effective rate and incidence of adverse reactions were compared between the two groups.

  Results  After treatment, compared with the ranitidine group, H⁺-K⁺-ATPase activity was lower and gastric pH value was higher that those in the combined treatment group (P < 0.05). After treatment, compared with the ranitidine group, the levels of IL-17, IL-6, IL-8, LPO and CD8⁺ were lower in the combined treatment group, while the levels of GSH-Px, CD3⁺ and CD4⁺ were higher in the combined treatment group (P < 0.05). The total effective rate in the combined treatment group was higher than that in the ranitidine group (P < 0.05).

  Conclusion  The use of proton pump inhibitors combined with ranitidine has a significant effect in treating patients with peptic ulcer, and can regulate the level of GSH-Px and LPO, improve self-immunity, inhibit inflammatory reaction, relieve the damage of oxidative stress, and improve the therapeutic effect.