Objective To explore the diagnostic value of serum heart-type fatty acid binding protein (H-FABP) and non-esterified fatty acid (NEFA) for myocardial injury after percutaneous coronary intervention (PCI) in elderly patients with coronary heart disease.
Methods A total of 104 patients with coronary heart disease who underwent PCI were selected as research objects. According to whether myocardial injury occurred after 3 months of treatment, they were divided into myocardial injury group (32 cases) and non-myocardial injury group (72 cases). The clinical information of all patients were collected. Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum H-FABP and NEFA levels; the Gensini scoring method was used to assess the degree of coronary artery disease before surgery; Pearson method was used to analyze the correlations between H-FABP, NEFA levels and troponin I (cTnI); the receiver operating characteristic (ROC) curve was used to evaluate the values of detection of serum H-FABP level or NEFA level alone or their combination in diagnosing myocardial injury in patients with coronary heart disease after PCI.
Results Compared with the non-myocardial injury group, the preoperative Gensini score, cTnI, low-density lipoprotein cholesterol (LDL-C) levels, H-FABP level, and NEFA level were higher in the myocardial injury group, the time from onset to treatment was longer, the high-density lipoprotein cholesterol (HDL-C) level was lower (P < 0.05). Serum H-FABP level and NEFA level in patients with myocardial injury were positively correlated with cTnI (P < 0.05). ROC curve showed that the area under the curve (AUC) of serum H-FABP and NEFA levels in the diagnosis of myocardial injury after PCI in patients with coronary heart disease was 0.873 and 0.816, respectively, and the sensitivity was 82.90% and 71.40%, respectively and the specificity was 90.30% and 90.30% respectively. The AUC of the H-FABP combined with NEFA in diagnosis of myocardial injury in patients with coronary heart disease after PCI was 0.941, and the sensitivity and specificity were 94.30% and 90.30%, respectively.
Conclusion The serum H-FABP and NEFA are highly expressed in patients with myocardial injury after PCI for coronary heart disease. H-FABP and NEFA can predict myocardial injury in patients with coronary heart disease after PCI, and their combined diagnosis value is better.
DownLoad: