Effect of Sini Shengjiang Powder in improving non-invasive hemodynamic indexes of sepsis capillary leakage syndrome

Objective To observe the effect of Sini Shengjiang Powder in improving non-invasive hemodynamic indexes of sepsis capillary leakage syndrome. Methods A total of 92 subjects were randomly divided into control group and treatment group, with 46 cases in each group. The treatment group was treated with Sini Shengjiang Powder on the basis of conventional treatment, and the control group was additionally treated with placebo of Sini Shengjiang Powder. The treatment lasted for 7 days. Thoracic fluid content (TFC), cardiac output (CO), cardiac index (CI), stroke volume(SV), stroke index (SI), stroke volume variation (SVV), systemic vascular resistance(SVR), systemic vascular resistance index (SVRI) before treatment (T₀), on the third day(T₁) and seventh day (T₂) were compared. Acute physiology and chronic health score Ⅱ(APACHE Ⅱ), sequential organ failure score (SOFA) and TCM syndrome score were recorded between the two groups. The use rate of continuous renal replacement therapy (CRRT), 28 day mortality and hospital stay were compared between the two groups. Results There were significant differences in CO, CI, SV and SI at T₁ and T₂ between the treatment group and the control group (P<0.05). There were statistically significant differences in SVV, SVR and SVRI at T₂ between the treatment group and the control group (P<0.05). The APACHE Ⅱ score, SOFA score and TCM syndrome score at T₂ of the treatment group showed significant differences when compared with T₁ and the control group (P<0.05). The use rate of CRRT, 28-day fatality rate in the treatment group were lower, and length of hospital stay was shorter than those in the control group (P<0.05). Conclusion Non-invasive hemodynamics can be used to evaluate the clinical efficacy of septic capillary leakage syndrome. Sini Shengjiang Powder can reduce the level of pleural fluid, enhance the function of heart pump, and reduce the fluid load in patients, so as to stabilize the hemodynamic state and improve the prognosis of patients with sepsis capillary leakage syndrome.