Related risk factors of cardiac insufficiency in patients with acute exacerbation of chronic obstructive pulmonary disease and their relationships with prognosis

  Objective  To analyze the related risk factors of cardiac insufficiency in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and their relationships with prognosis.

  Methods  A total of 104 patients with AECOPD were selected as study objects, and were divided into cardiac insufficiency group (n=62) and non-cardiac insufficiency group (n=42) according to the presence or absence of cardiac insufficiency. Logistic regression model was used to analyze the influencing factors of cardiac insufficiency in patients with AECOPD, and the prognostic influencing factors of AECOPD.

  Results  There were statistically significant differences in the confirmed diagnosis time of COPD, the number of acute exacerbation in the past one year, hypoalbuminemia, partial pressure of carbon dioxidep_a(CO₂), and C-reactive protein (CRP) levels between the cardiac insufficiency group and non-cardiac insufficiency group (P < 0.05). The level of p_a(CO₂), the number of acute exacerbation in the past one year, and hypoalbuminemia were independent risk factors for cardiac insufficiency in patients with AECOPD (P < 0.05). There were statistically significant differences in age, red blood cell distribution width (RDW) and serum uric acid (UA) after treatment, pulmonary function classification, hypoalbuminemia, cardiac insufficiency and New York Heart Association (NYHA) cardiac function classification between the good prognosis group and the poor prognosis group (P < 0.05). Age, hypoalbuminemia, pulmonary function classification, cardiac insufficiency and NYHA cardiac function classification were independent risk factors influencing the prognosis of patients with AECOPD (P < 0.05).

  Conclusion  The main risk factors for cardiac insufficiency in patients with AECOPD include increased p_a(CO₂), increased times of acute exacerbation in the past one year, and hypoalbuminemia. Cardiac insufficiency and its severity are closely related to the patients' prognosis, which can increase the risk of poor prognosis.