Objective To analyze the multi-drug resistance in elderly patients with pulmonary infection and respiratory failure undergoing mechanical ventilation and related factor analysis.
Methods A total of 265 elderly patients with pulmonary infection and respiratory failure were included in this study. One hundred and thirty-nine patients without multi-drug resistance were included in the routine group, and 126 patients with multi-drug resistance were included in the study group. The general data of the two groups and the test results of drug-resistant bacteria were collected, and risk factors in the study group were analyzed.
Results A total of 277 strains of pathogenic bacteria were detected in this study, including 144 strains in the study group and 133 strains in the conventional group. Gram-negative bacteria were the main strains (46.93% in the study group and 31.05% in the routine group). Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae all showed multi-drug resistance, and Klebsiella pneumoniae showed the highest drug resistance. Age older than 70 years, history of tracheotomy and intubation, mechanical ventilation time ≥ 7 days are all risk factors for multiple drug resistance (P < 0.05).
Conclusion Age older than 70 years old, history of tracheotomy and intubation, mechanical ventilation ≥ 7 days are all important risk factors for multiple drug resistance after mechanical ventilation in elderly patients with pulmonary infection and respiratory failure. In clinical practice, appropriate antimicrobial agents should be selected according to the results of drug sensitivity test, and drug dosage should be reasonably controlled to reduce the probability of multi-drug resistance.
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