Efficacy observation on sequential therapy with teriparatide and bisphosphonates for senile patients with osteoporosis

  Objective  To investigate the clinical efficacy and safety of sequential therapy with teriparatide and bisphosphonates for senile patients with osteoporosis.

  Methods   Totally 72 senile patients with osteoporosis were randomly divided into control group (zoledronic acid) and study group (sequential therapy with teriparatide and zoledronic acid), with 36 cases in each group. Before and after treatment, the score of Visual Analogue Scale (VAS), the bone mineral density values of different parts (lumbar spine, femoral neck and hip), the levels of bone metabolism indexes blood calcium, blood phosphorus, bone Gla-protein (BGP) and alkaline phosphatase (ALP), adverse reactions and incidence rate of fracture were compared between the two groups.

  Results   After treatment, the VAS scores in both groups were significantly lower than that before treatment (P < 0.05), and the VAS score of the study group was significantly lower than that of the control group (P < 0.05). After treatment, the bone mineral density values of lumbar spine, femoral neck and hip in both groups were significantly higher than those before treatment (P < 0.05), and the bone mineral density values of different parts in the study group were significantly higher than those in the control group (P < 0.05). After treatment, the levels of blood calcium and blood phosphorus in the control group were significantly higher than those before treatment (P < 0.05), the levels of blood calcium, blood phosphorus, BGP and ALP in the study group were significantly higher than those before treatment (P < 0.05), and the levels of blood phosphorus and BGP in the study group were significantly higher than those in the control group (P < 0.05). There were no significant differences in the incidence rates of adverse reactions and fracture between the two groups (P > 0.05).

  Conclusion   Sequential therapy with teriparatide and bisphosphonate is effective and safe in treatment of senile patients with osteoporosis, which can relieve pain, increase bone mineral density and improve bone metabolism.