Three cases of type Ⅱ autoimmune polyendocrine syndrome with different diseases composition

  Objective  To analyze the clinical characteristics of patients with autoimmune polyendocrine syndrome (APS).

  Methods  The composition and main clinical manifestations of autoimmune diseases in 3 patients with APS Ⅱ were analyzed.

  Results  Three patients presented with different symptoms of cortical hypofunction, islet failure, hypothyroidism with hypocalcemia. Multiple endocrine glands and non-endocrine organs were involved in the course of the disease.

  Conclusion  The onset of APS is insidious, and the time from one gland disease to another or more gland diseases is uncertain, which is easy to be missed in diagnosis and delayed in treatment. At the time of diagnosis, routine screening and long-term follow-up are needed for early diagnosis and treatment.