Diagnosis accuracy of acute myocardial infarction in patients with renal injury using high-sensitivity troponin T

LI Guangquan; ZHONG Peiying

doi:10.7619/jcmp.20211396

Journal of Clinical Medicine in Practice > 2021 > 25(11): 85-88. > DOI: 10.7619/jcmp.20211396

LI Guangquan, ZHONG Peiying. Diagnosis accuracy of acute myocardial infarction in patients with renal injury using high-sensitivity troponin T[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 85-88. DOI: 10.7619/jcmp.20211396

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Diagnosis accuracy of acute myocardial infarction in patients with renal injury using high-sensitivity troponin T

Department of Laboratory Medicine, 363^rd Hospital, Chengdu, Sichuan, 610016

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Received Date: March 28, 2021
Available Online: June 14, 2021
Published Date: June 14, 2021

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Abstract

Abstract

Objective To investigate the diagnostic accuracy of high-sensitivity cardiac troponin T (hs-cTnT) in patients with acute myocardial infarction (AMI) with renal damage.
Methods A total of 1 934 patients with chest pain were divided into different groups based on different estimated glomerular filtration rate (eGFR). There were 689 cases in the group of eGFR ≥90 mL/(min·1.73 m²)[chronic kidney disease (CKD) Ⅰ stage], 889 cases in the group of eGFR 60 to < 90 mL/(min·1.73 m²) (CKDⅡ stage), 283 cases in the group eGFR 30 to < 60 mL/(min·1.73 m²) (CKD Ⅲ stage) and 73 cases in the eGFR < 30 mL/(min·1.73 m²) group (CKD Ⅳ stage). Receiver operating characteristic (ROC) curve was used to compare the diagnostic performance between the threshold and the 99th percentile.
Results When eGFR < 30 mL/(min·1.73 m²), eGFR 30 to < 60 mL/(min·1.73 m²) and eGFR 60 to < 90 mL/(min·1.73 m²). Compared with the corresponding sensitivity, specificity, positive predictive value and negative predictive value of the 99th percentile, and the differences in those of the ROC determination threshold were statistically significant (P < 0.01).
Conclusion For AMI patients with kidney damage, the ROC threshold hs-cTnT should be combined with eGFR for accurate diagnosis.

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[1]	MCCARTHY C P, RABER I, CHAPMAN A R, et al. Myocardial injury in the era of high-sensitivity cardiac troponin assays: a practical approach for clinicians[J]. JAMA Cardiol, 2019, 4(10): 1034-1042. doi: 10.1001/jamacardio.2019.2724
[2]	ROCCO E, LA ROSA G, LIUZZO G, et al. High-sensitivity cardiac troponin assays and acute coronary syndrome: a matter of sex[J]. J Cardiovasc Med Hagerstown Md, 2019, 20(8): 504-509. doi: 10.2459/JCM.0000000000000811
[3]	ZHAO B C, ON BEHALF OF THE PREVENTION OF VASCULAR EVENTS AFTER NON-CARDIAC SURGERY (PREVENGE) INVESTIGATORS, LIU W F, et al. Meta-analysis of preoperative high-sensitivity cardiac troponin measurement in non-cardiac surgical patients at risk of cardiovascular complications[J]. Br J Surg, 2020, 107(2): e81-e90. doi: 10.1002/bjs.11305
[4]	KARADAŞ U, KARADAŞ N Ö, BAK M, et al. The role of cardiac troponin T in detection of cardiac damage and long term mortality in children with chronic renal disease[J]. Turk J Pediatr, 2019, 61(6): 873-878. doi: 10.24953/turkjped.2019.06.008
[5]	丁红梅, 储楚, 杨瑞霞, 等. 高敏肌钙蛋白T和肌红蛋白在肾功能不全患者中的变化及意义[J]. 国际检验医学杂志, 2018, 39(14): 1708-1711. doi: 10.3969/j.issn.1673-4130.2018.14.013
[6]	FENG J F, QIU L, ZHANG L, et al. Multicenter study of creatinine-and/or cystatin C-based equations for estimation of glomerular filtration rates in Chinese patients with chronic kidney disease[J]. PLoS One, 2013, 8(3): e57240. doi: 10.1371/journal.pone.0057240
[7]	DELONG E R, DELONG D M, CLARKE-PEARSON D L. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach[J]. Biometrics, 1988, 44(3): 837-845. doi: 10.2307/2531595
[8]	DI LULLO L, BARBERA V, SANTOBONI A, et al. Malattia renale cronica e syndrome coronarica acuta: il ruolo della troponina[Troponins and chronic kidney disease] [J]. G Ital Nefrol, 2015, 32(4): gin/32. 4. 1. https://air.unimi.it/retrieve/handle/2434/344592/430234/Troponina%20GIN.pdf
[9]	JAIN N, HEDAYATI S S. How should clinicians interpret cardiac troponin values in patients with ESRD[J]. Semin Dial, 2011, 24(4): 398-400. doi: 10.1111/j.1525-139X.2011.00912.x
[10]	DIRIS J H, HACKENG C M, KOOMAN J P, et al. Impaired renal clearance explains elevated troponin T fragments in hemodialysis patients[J]. Circulation, 2004, 109(1): 23-25. doi: 10.1161/01.CIR.0000109483.45211.8F
[11]	肖文凯, 叶平. 慢性肾脏病患者血清高敏肌钙蛋白T水平变化及意义[J]. 中华老年心脑血管病杂志, 2015, 17(5): 546-548. doi: 10.3969/j.issn.1009-0126.2015.05.031
[12]	李广权, 黄华兰, 贺勇, 等. 高敏肌钙蛋白T检测在老年急性心肌梗死患者诊断中的价值[J]. 国际检验医学杂志, 2015, 36(4): 451-453. doi: 10.3969/j.issn.1673-4130.2015.04.009
[13]	朱秀菊, 王艳华, 沈芳. 高敏cTnI在急性心肌梗死患者中的诊断阈值与影响因素分析[J]. 国际检验医学杂志, 2016, 37(18): 2545-2547. doi: 10.3969/j.issn.1673-4130.2016.18.015
[14]	SHIGEMURA M, KONNO S, NASUHARA Y, et al. Impact of asthmatic control status on serum cystatin C concentrations[J]. Clin Chem Lab Med, 2012, 50(8): 1367-1371. http://test.europepmc.org/abstract/MED/23035264
[15]	ALHUSSEINY A H, AL-NIMER M S M, AL-NEAMY S I A. Assessment of serum cystatin C levels in newly diagnosed acute myocardial infarction at the onset and at the time of hospital discharge[J]. Cardiol Res, 2015, 6(1): 226-231. doi: 10.14740/cr377w
[16]	TARAPAN T, MUSIKATAVORN K, PHAIRATWET P, et al. High sensitivity Troponin-I levels in asymptomatic hemodialysis patients[J]. Ren Fail, 2019, 41(1): 393-400. doi: 10.1080/0886022X.2019.1603110

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Diagnosis accuracy of acute myocardial infarction in patients with renal injury using high-sensitivity troponin T

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