Efficacy of Shengjiang Powder enema in treatment of ventilator associated pneumonia with phlegm heat obstructing the lung and its mechanism

  Objective  To observe the clinical efficacy of Shengjiang Powder enema in treatment of ventilator associated pneumonia with phlegm heat obstructing the lung and its safety.

  Methods  Sixty-two patients with ventilator associated with pneumonia (TCM syndrome differentiation as phlegm-heat the lung type) were randomly divided into treatment group (n=30) and control group (n=32). Both groups were treated with conventional western medicine, and the treatment group was combined with shengjiang Powder enema based on the control group.

  Results  White blood cell (WBC) count, C-reactive protein (CRP), procalcitonin (PCT), Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ, clinical pulmonary infection score(CPIS) and the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-2R (IL-2R), interleukin-6 (IL-6) and interleukin-8 (IL-8) were significantly lower, and interleukin-10 (IL-10) as well as oxygenation indexp_a(O₂)/FiO₂ in the two groups were significantly higher than those before treatment (P < 0.05); WBC, CRP, PCT, APACHE Ⅱ score, CPIS score, TNF-α, IL-1β, IL-2R, IL-6, IL-8 in the treatment group were significantly lower, duration of mechanical ventilation and length of ICU stay were significantly shorter, and IL-10 and p_a(O₂)/FiO₂ were significantly higher than those in the control group (P < 0.05). The effective rate of the treatment group was significantly higher than that of control group (P < 0.05). No serious adverse events were recorded during the study.

  Conclusion  Shengjiang Poweran enema can inhibit the inflammatory reaction of patients with ventilator associated pneumonia with phlegm heat obstructing the lung, reduce the APACHE Ⅱ score and CPIS score of patients, shorten the length of ICU stay and mechanical ventilation time, and improve the efficacy.