Effect of percutaneous coronary intervention guided by intravascular ultrasound in treatment of patientswith borderline lesions of non-ST elevated acute coronary syndrome

  Objective  To investigate the effects of percutaneous coronary intervention (PCI) guided by intravascular ultrasound (IVUS) on plasma brain natriuretic peptide (BNP), high sensitivity C reactive protein (hs-CRP) and major adverse cardiovascular events (MACE) in patients with borderline lesions of non-ST segment elevated acute coronary syndrome (NSTE-ACS).

  Methods  Clinical materials of 65 patients with borderline lesions of NSTE-ACS by PCI were analyzed retrospectively, and they were divided into IVUS group (n=33) and fractional flow reserve (FFR) group (n=32) according to PCI guidance. The PCI status and the change of plasma BNP and hs-CRP levels before and after the operation were compared. The patients were followed up for 12 months, and the incidence of MACE was compared between the two groups.

  Results  At the moment of admission, there were no significant differences in plasma BNP and hs-CRP levels between the two groups (P>0.05). On the 7^th day after operation, the plasma levels of BNP and hs-CRP in both groups were significantly lower than those at the moment of admission, and those indexes in the IVUS group were significantly lower than the FFR group (P < 0.05). There were no significant differences in MACE and recurrent angina between the two groups (P>0.05).

  Conclusion  PCI guided by IVUS can improve the levels of BNP and hs-CRP in patients with borderline lesions of NSTE-ACS and will not increase the occurrence risk of MACE.