Expression and significance of serum chemokine and fibroblast growth factor 21 in patients with diabetic retinopathy

  Objective  To observe expressions of serum chemokine and fibroblast growth factor 21(FGF21) in patients with diabetic retinopathy in serum of diabetic retinopathy and their values in diagnosing diabetic retinopathy.

  Methods  A total of 90 patients with diabetic retinopathy admitted to our hospital were selected as observation group. At the same time, 85 people with physical examinations were randomly selected as control group. Serum Chemerin, FGF21, glycosylated hemoglobin(HbAlc), fasting blood glucose (FBG) levels were compared between the two groups, and the levels of Chemerin, FGF21, HBALC, FBG in diabetic retinopathy patients with different severity of disease were compared. The correlations between serum Chemerin, FGF21 and HbAlc, FBG were analyzed, and the diagnostic value of serum Chemerin and FGF21 in diabetic retinopathy was evaluated by Receiver Operating Characteristic (ROC) curve.

  Results  The serum levels of Chemerin and FGF21 in the observation group were significantly higher than those in the control group (P < 0.05). Serum levels of Chemerin and FGF21 in the proliferative diabetic retinopathy patients were significantly higher than those with nonproliferative diabetic retinopathy (P < 0.05). The correlation analysis results showed that Chemerin and FGF21 were significantly positively correlated with HbAlc and FBG, respectively The serum levels of Chemerin and FGF21 in the observation group were significantly higher than those in the control group (P < 0.05). Serum levels of Chemerin and FGF21 in the proliferative diabetic retinopathy patients were significantly higher than those with nonproliferative diabetic retinopathy (P < 0.05). The correlation analysis results showed that Chemerin and FGF21 were significantly positively correlated with HbAlc and FBG, respectively with prognosis (P < 0.05). ROC curve evaluation results showed that the sensitivity, specificity and accuracy of serum combined detection of Chemerin and FGF21 in the diagnosis of diabetic retinopathy were higher than those of single detection (P < 0.05).

  Conclusion   The expressions of serum Chemerin and FGF21 in patients with diabetic retinopathy are closely related to the levels of HbAlc and FBG, which can be used as markers for early differential diagnosis of diabetic retinopathy, and combined detection has a high diagnostic value for diabetic retinopathy.