Analysis in efficacy of autologous platelet-rich fibrin in the treatment of infertility due to intrauterine adhesions

  Objective   To evaluate the efficacy of autologous platelet-rich fibrin (PRF) in the treatment of infertility due to intrauterine adhesion.

  Methods   From October 2018 to October 2019, 40 patients diagnosed as intrauterine adhesion and excluded other infertility factors in Beijing Shijitan Hospital were randomly divided into PRF group and control group, with 20 cases in each group. The intervention lasted for 8 weeks. Patients in both groups underwent transcervical resection of adhesion (TCRA), and PRF was placed in the uterine cavity immediately after TCRA and 4 weeks later in the PRF group. After 8 weeks of TCRA, a second hysteroscopy was performed, and then follow-up was performed. Pregnancy rate, intrauterine adhesions score, menstruation, and endometrial thickness (EMT) were compared between two groups.

  Results   The pregnancy rate of the PRF group was 70.00%, which was significantly higher than 20.00% of the control group (P < 0.01). The adhesions score of the PRF group was significantly lower than that of the control group, and the improvement of menstrual duration was significantly better than that of the control group (P < 0.05 or P < 0.01). The menstrual volume and EMT in both groups were improved, but there were no significant differences between two groups (P>0.05).

  Conclusion   The placement of PRF combined with the TCRA can improve the pregnancy rate of infertility due to intrauterine adhesion, reduce intrauterine adhesion scores, and improve clinical symptom.