Value of percutaneous lung puncture and biopsy combined with detection of tumor markers in diagnosis of pulmonary occupying lesions

Objective To explore the application value of CT-guided percutaneous lung puncture and biopsy combined with tumor markers detection in diagnosis of pulmonary occupying lesions. Methods A total of 206 patients with pulmonary occupying lesions were selected as study objects, and all underwent CT-guided percutaneous lung puncture and biopsy combined with tumor markers detection. Taking surgical pathologic examination results as gold standard, the application value of CT-guided percutaneous lung puncture and biopsy combined with tumor markers detection in pulmonary occupying lesions was analyzed. Patients with malignant lesions were included in the malignant group and those with benign lesions were included in the benign group, and the levels of tumor markers in the two groups were compared. Results The levels of NSE and CEA in the malignant group were higher than those in the benign group, and the differences were statistically significant(P<0.05); the receiver operating characteristic curve(ROC)found that the AUCs of NSE and CEA for the diagnosis of benign and malignant lung lesions were 0.812 and 0.805, respectively; the sensitivity, specificity and accuracy of NSE detection in diagnosis of lung space-occupying lesions were 69.54%, 70.91% and 69.90%, respectively. The sensitivity, specificity and accuracy of CEA detection in diagnosis of lung space-occupying lesions were 70.20%, 67.27% and 69.42% respectively. The sensitivity, specificity and accuracy of CT-guided percutaneous lung biopsy in the diagnosis of lung space-occupying lesions were 92.05%, 81.82% and 89.32%. The sensitivity, specificity and accuracy of CT guided percutaneous lung biopsy combined with tumor markers detecting in the diagnosis - of lung space-occupying lesions were 96.03%, 83.64% and 92.72%. ROC found that the AUC of CT guided percutaneous lung biopsy combined with tumor markers detection in the diagnosis of benignand malignant pulmonary lesions was 0.911. Conclusion CT-guided percutaneous lung puncture and biopsy combined with tumor markers detection has higher diagnostic value in pulmonary occupying lesions and can improve the diagnostic accuracy of malignant lung diseases