Advance Search
YU Shuyan, YANG Yi, HU Ting, CAO Yanpei. Expression of interleukin-13 receptor α2 in cancer cells of colorectal cancer patients with liver metastasis and its relationship with myeloid-derived suppressor cells[J]. Journal of Clinical Medicine in Practice, 2020, 24(23): 65-69. DOI: 10.7619/jcmp.202023021
Citation: YU Shuyan, YANG Yi, HU Ting, CAO Yanpei. Expression of interleukin-13 receptor α2 in cancer cells of colorectal cancer patients with liver metastasis and its relationship with myeloid-derived suppressor cells[J]. Journal of Clinical Medicine in Practice, 2020, 24(23): 65-69. DOI: 10.7619/jcmp.202023021
shu

Expression of interleukin-13 receptor α2 in cancer cells of colorectal cancer patients with liver metastasis and its relationship with myeloid-derived suppressor cells

  • 1. Department of General Surgery, 2. Nursing Department, Huashan Hospital Affiliated to Fudan University, Shanghai, 200041

More Information
  • Received Date: October 14, 2020
  • Available Online: December 20, 2020
    Graphical Abstract
    • Abstract
  • Objective To investigate the expression of interleukin-13 receptor α2(IL-13Rα2)in cells of colorectal cancer patients with liver metastasis and its relationship with myeloid-derived suppressor cells(MDSCs). Methods Paraffin sections of 68 patients with colorectal cancer surgery in Huashan Hospital Affiliated to Fudan University from 2000 to 2013 were retrospectively analyzed. The expression of IL-13Rα2 was observed after routine immunostaining. Anti-CD11B antibody and anti-CD33 antibody were used for double staining. Fluorescent antibody, goat anti-rabbit immunoglobulin(H+L)antibody and goat anti-mouse immunoglobulin(H+L)antibody were used to display CD33. Three pathologists independently evaluated IL-13Rα2 stained slides in a double-blind manner. Results The positive rate of IL-13Rα2 in colorectal cancer patients with liver metastasis was the highest(90.8%), followed by brain metastasis(65.0%), primary lesions(60.0%), and other metastases(53.0%), and there were significant differences(P<0.05). There was a linear correlation between the expression of IL-13Rα2 and the number of MDSCs in cases with liver metastasis(r=0.740, P<0.05). The average survival time of 48 patients with distant metastasis was(12.6±5.2)months. Conclusion The increased level of IL-13Rα2 suggests that the prognosis of colorectal cancer patients with distant metastasis is poor, and it is speculated that IL-13Rα2 can induce proliferation of MDSCs and promote liver metastasis by regulating colorectal cancer cells.
    • FullText(HTML)
    • References (32)
  • FERLAY J, SHIN H R, BRAY F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008[J]. Int J Cancer, 2010, 127(12): 2893-2917.
    FONG Y, COHEN A M, FORTNER J G, et al. Liver resection for colorectal metastases[J]. J Clin Oncol, 1997, 15(3): 938-946.
    ABDALLA E K, RIBERO D, PAWLIK T M, et al. Resection of hepatic colorectal metastases involving the caudate lobe: perioperative outcome and survival[J]. J Gastrointest Surg, 2007, 11(1): 66-72.
    LEPORRIER J, MAUREL J, CHICHE L, et al. A population-based study of the incidence, management and prognosis of hepatic metastases from colorectal cancer[J]. Br J Surg, 2006, 93(4): 465-474.
    RUERS T J, WIERING B, VAN DER SIJP J R, et al. Improved selection of patients for hepatic surgery of colorectal liver metastases with(18)F-FDG PET: a randomized study[J]. J Nucl Med, 2009, 50(7): 1036-1041.
    WYNN T A. IL-13 effector functions[J]. Annu Rev Immunol, 2003, 21: 425-456.
    FUJISAWA T, JOSHI B, NAKAJIMA A, et al. A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis[J]. Cancer Res, 2009, 69(22): 8678-8685.
    MANDAL D, LEVINE A D. Elevated IL-13Ralpha2 in intestinal epithelial cells from ulcerative colitis or colorectal cancer initiates MAPK pathway[J]. Inflamm Bowel Dis, 2010, 16(5): 753-764.
    HUSAIN S R, JOSHI B H, PURI R K. Interleukin-13 receptor as a unique target for anti-glioblastoma therapy[J]. Int J Cancer, 2001, 92(2): 168-175.
    OSTRAND-ROSENBERG S. Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity[J]. Cancer Immunol Immunother, 2010, 59(10): 1593-1600.
    GABRILOVICH D. Mechanisms and functional significance of tumour-induced dendritic-cell defects[J]. Nat Rev Immunol, 2004, 4(12): 941-952.
    OSTRAND-ROSENBERG S, SINHA P. Myeloid-derived suppressor cells: linking inflammation and cancer[J]. J Immunol, 2009, 182(8): 4499-4506.
    SICA A, BRONTE V. Altered macrophage differentiation and immune dysfunction in tumor development[J]. J Clin Invest, 2007, 117(5): 1155-1166.
    GABITASS R F, ANNELS N E, STOCKEN D D, et al. Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13[J]. Cancer Immunol Immunother, 2011, 60(10): 1419-1430.
    HALL B, NAKASHIMA H, SUN Z J, et al. Targeting of interleukin-13 receptor α2 for treatment of head and neck squamous cell carcinoma induced by conditional deletion of TGF-β and PTEN signaling[J]. J Transl Med, 2013, 11: 45.
    JEMAL A, BRAY F, CENTER M M, et al. Global cancer statistics[J]. CA: A Cancer J Clin, 2011, 61(2): 69-90.
    SIMMONDS P C, PRIMROSE J N, COLQUITT J L, et al. Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies[J]. Br J Cancer, 2006, 94(7): 982-999.
    CHIARAMONTE M G, MENTINK-KANE M, JACOBSON B A, et al. Regulation and function of the interleukin 13 receptor α 2 during a T helper cell type 2–dominant immune response[J]. J Exp Med, 2003, 197(6): 687-701.
    FICHTNER-FEIGL S, STROBER W, KAWAKAMI K, et al. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis[J]. Nat Med, 2006, 12(1): 99-106.
    JOSHI B H, PLAUTZ G E, PURI R K. Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas[J]. Cancer Res, 2000, 60(5): 1168-1172.
    KAWAKAMI M, KAWAKAMI K, KASPERBAUER J L, et al. Interleukin-13 receptor alpha2 chain in human head and neck cancer serves as a unique diagnostic marker[J]. Clin Cancer Res, 2003, 9(17): 6381-6388.
    PURI R K, LELAND P, OBIRI N I, et al. Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A(PE38QQR)[J]. Blood, 1996, 87(10): 4333-4339.
    MINN A J, GUPTA G P, SIEGEL P M, et al. Genes that mediate breast cancer metastasis to lung[J]. Nature, 2005, 436(7050): 518-24.
    FUJISAWA T, JOSHI B, NAKAJIMA A, et al. A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis[J]. Cancer Res, 2009, 69(22): 8678-8685.
    BARDERAS R, BARTOLOMÉR A, FERNANDEZ-ACEÑERO M J, et al. High expression of IL-13 receptor α2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosis[J]. Cancer Res, 2012, 72(11): 2780-2790.
    APRILE G, DE MAGLIO G, MENIS J, et al. HER-2 expression in brain metastases from colorectal cancer and corresponding primary tumors: a case cohort series[J]. Int J Mol Sci, 2013, 14(2): 2370-2387.
    RODRIGUEZ P C, ZEA A H, DESALVO J, et al. L-arginine consumption by macrophages modulates the expression of CD3 Zeta chain in T lymphocytes[J]. J Immunol, 2003, 171(3): 1232-1239.
    RODRIGUEZ P C, QUICENO D G, ZABALETA J, et al. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses[J]. Cancer Res, 2004, 64(16): 5839-5849.
    NAGARAJ S, GUPTA K, PISAREV V, et al. Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer[J]. Nat Med, 2007, 13(7): 828-835.
    HOECHST B, ORMANDY L A, BALLMAIER M, et al. A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4+CD25+Foxp3+ T cells[J]. Gastroenterology, 2008, 135(1): 234-243.
    KO J S, ZEA A H, RINI B I, et al. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients[J]. Clin Cancer Res, 2009, 15(6): 2148-2157.
    HALL B, NAKASHIMA H, SUN Z J, et al. Targeting of interleukin-13 receptor α2 for treatment of head and neck squamous cell carcinoma induced by conditional deletion of TGF-β and PTEN signaling[J]. J Transl Med, 2013, 11: 45-53.
    • Related Articles

Catalog

    Get Citation
    PDF
    XML
    Article views PDF downloads Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return