Advance Search
XU Gang. Value of combined detection of urinary albumin-to-creatinine ratio, β2 microglobulin and retinol binding protein in early diagnosis of diabetic nephropathy[J]. Journal of Clinical Medicine in Practice, 2020, 24(21): 86-89. DOI: 10.7619/jcmp.202021025
Citation: XU Gang. Value of combined detection of urinary albumin-to-creatinine ratio, β2 microglobulin and retinol binding protein in early diagnosis of diabetic nephropathy[J]. Journal of Clinical Medicine in Practice, 2020, 24(21): 86-89. DOI: 10.7619/jcmp.202021025
shu

Value of combined detection of urinary albumin-to-creatinine ratio, β2 microglobulin and retinol binding protein in early diagnosis of diabetic nephropathy

  • Department of Clinical Laboratory, Baoshan Branch of Renji Hospital in Shanghai, 200436

More Information
  • Received Date: August 12, 2020
  • Available Online: December 21, 2020
  • Published Date: November 23, 2020
    Graphical Abstract
    • Abstract
  • Objective To investigate the value of urinary albumin-to-creatinine ratio(ACR), β2 microglobulin(β2-MG)and retinol binding protein(RBP)in early diagnosis of renal damage in diabetic patients. Methods A total of 96 patients with diabetes who were treated in our hospital were selected as research objects, and were divided into diabetic nephropathy group(n=49)and diabetes group(n=47)according to the qualitative test results of urinary protein. Another 50 healthy patients who underwent physical examination in the outpatient department during the same period were selected as healthy group. The levels of ACR, β2-MG and RBP were detected and compared in three groups, and sensitivity, specificity and accuracy of detection of ACR, β2-MG or RBP alone and their combination were calculated. Results The levels of urinary ACR, β2-MG and RBP in the diabetic nephropathy group were significantly higher than those in diabetes group and healthy group(P<0.05). The positive rates of detection of ACR, β2-MG or RBP alone and their combination in the diabetic nephropathy group were significantly higher than that in the diabetes group(P<0.05). The sensitivity, specificity and accuracy of combined detection of urinary ACR, β2-MG and RBP in diagnosis of diabetic nephropathy were 95.92%, 85.57% and 89.04%, respectively, and there were significant differences in sensitivity and accuracy between single detection and combined detection(P<0.05), but no significant difference was found in specificity(P>0.05). Conclusion Urinary ACR, β2-MG and RBP levels can reflect early renal injury degree in diabetic patients, and combined detection has better - sensitivity and accuracy in diagnosis of diabetic nephropathy.
    • FullText(HTML)
    • References (16)
  • 梁霞, 田甜, 赵爱巧, 等. 尿ACR联合尿β2-MG检测在妊娠合并糖尿病早期肾损害诊断中的临床应用[J]. 临床与病理杂志, 2018, 38(9): 1890-1896.
    梁涛, 张晓宝, 张德太, 等. 3项指标联合检测在糖尿病肾病中的早期诊断价值[J]. 临床血液学杂志: 输血与检验, 2019, 32(4): 247-251.
    梁霞, 韩翠欣, 刘欢, 等. 尿微量白蛋白与尿肌酐比值、尿微量白蛋白及尿β2-微球蛋白检测诊断妊娠期糖尿病早期肾损害的价值[J]. 现代中西医结合杂志, 2019, 11(23): 2544-2547.
    黄斯伟. 糖尿病肾病血清α1-微球蛋白和β2-微球蛋白联合尿视黄醇结合蛋白检测价值研究[J]. 中国预防医学杂志, 2019, 20(3): 233-235.
    刘莉, 张军. 血清Cys C、β2-MG与尿kim-1、M-ALB联合检测在早期糖尿病肾病诊断中的价值[J]. 检验医学与临床, 2018, 15(23): 3515-3517.
    黎明, 徐雯. 血清同型半胱氨酸、血清胱抑素-C、尿β2-微球蛋白联合检测对早期诊断糖尿病肾病准确性分析[J]. 国际免疫学杂志, 2018, 41(4): 430-433.
    刘辉, 孙懿, 姚英. 肾小管损伤标志物检测对慢性肾脏病高危人群的意义及影响因素研究[J]. 临床肾脏病杂志, 2019, 22(9): 530-533.
    张翠静, 唐宏霞, 鲍喜静, 等. 血清中MicroRNA-130b表达在评估2型糖尿病患者早期肾脏损伤中的价值[J]. 中国临床医生杂志, 2018, 46(1): 35-38.
    吴惠兰, 毛春芬, 陈晓君. 联合检测血清降钙素原、血清前白蛋白和视黄醇结合蛋白对脓毒血症早期诊断的价值[J]. 中国医师进修杂志, 2019, 42(12): 1093-1096.
    苏洋, 梅秋雁. 血浆NGAL, Cys C和尿NAG/Crea联合检测对早期糖尿病肾病诊断价值的研究[J]. 现代检验医学杂志, 2018, 33(1): 99-101

    , 105.
    何艳红. 尿微量白蛋白和血清、尿β2微球蛋白联合检测在诊断糖尿病早期肾病的临床应用价值[J]. 临床检验杂志: 电子版, 2019, 8(4): 75-76.
    王雪, 蔡立夫, 王堃. 血清RBP、β2-MG、CysC水平联合检测对妊娠期糖尿病待产妇患者早期肾损害阳性检出率的影响[J]. 中国实验诊断学, 2019, 23(2): 266-268.
    杨琴, 王团美, 王曼知, 等. 联合检测尿微量白蛋白肌酐比值、尿视黄醇结合蛋白、血清胱抑素C早期诊断窒息新生儿肾功能损伤的意义[J]. 现代中西医结合杂志, 2018, 27(14): 1565-1567.
    张如霖, 王弘明, 彭霞, 等. 血清淀粉样蛋白A、胱抑素C与尿白蛋白/肌酐比值联合检测在早期糖尿病肾病中的诊断价值[J]. 检验医学, 2018, 33(2): 97-100.
    郑莹莹. 糖尿病患者血清胱抑素C、尿RBP水平变化及其与Scr和Ccr的关系[J]. 山东医药, 2019, 59(4): 64-66.
    罗丹. 5项指标联合检测对早期糖尿病肾病的诊断价值[J]. 检验医学与临床, 2019, 16(19): 2811-2813.
    • Related Articles

  • Related Articles

    [1]HE Jiaqin, WU Hongyan, CAI Qian, LU Yu, LIU Xinliang. Values of serum triglyceride-glucose index combined with retinol-binding protein and β2-microglobulin in prediction and screening of diabetic retinopathy[J]. Journal of Clinical Medicine in Practice, 2023, 27(18): 70-74. DOI: 10.7619/jcmp.20231267
    [2]FENG Feifei, WU Jiayu, JIANG Lili, XU Yan. Application of combined detection of red blood cell distribution width, ratio of C-reactive protein to albumin and albumin-to-creatinine ratio in predicting complications of type 2 diabetes[J]. Journal of Clinical Medicine in Practice, 2023, 27(15): 45-49. DOI: 10.7619/jcmp.20223479
    [3]HUA Yulin, ZHANG Yuyang, WANG Chen, SUN Hong, SHI Bimin. Application of renal fat detection technology in diabetic patients[J]. Journal of Clinical Medicine in Practice, 2022, 26(21): 136-139. DOI: 10.7619/jcmp.20222584
    [4]LIU Jianli, LIU Liming, YANG Xiaoying. Relationships between three islet autoantibodiesand renal damage in children with type 1 diabetes mellitus[J]. Journal of Clinical Medicine in Practice, 2021, 25(21): 119-123. DOI: 10.7619/jcmp.20212482
    [5]ZHANG Junfeng, LIU Shengxian, LI Jie. Value of combined detection of four indicators in diagnosis of early renal injury in elderly patients with essential hypertension[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 97-99. DOI: 10.7619/jcmp.202014026
    [6]YIN Haibin, ZHOU Cheng. Association between Helicobacter pylori infection and early renal damage in children with Henoch-Schonlein purpura[J]. Journal of Clinical Medicine in Practice, 2019, 23(24): 47-50, 54. DOI: 10.7619/jcmp.201924015
    [7]ZHAO Yani, WANG Jun, ZHAO Mian. Value of combined detection of serum β2-MG, RBP, Cys C, NGAL and MMP-2 in patients with diabetic nephropathy[J]. Journal of Clinical Medicine in Practice, 2018, (13): 20-23. DOI: 10.7619/jcmp.201813006
    [8]GUO Jin. Levels of serum retinol binding protein and cystatin C in patients with hemorrhagic fever with renal syndrome and their correlations with renal damage[J]. Journal of Clinical Medicine in Practice, 2017, (13): 48-50. DOI: 10.7619/jcmp.201713013
    [9]ZHANG Xiajun, HU Mengmou, YAN Xiaohui. Value of detection of serum P-selectin combined with microalbuminuria in early diagnosis of renal impairment of children with Henoch-Sch-nlein purpura[J]. Journal of Clinical Medicine in Practice, 2013, (23): 52-55. DOI: 10.7619/jcmp.201323015

Catalog

    Get Citation
    PDF
    XML
    Article views (357) PDF downloads (30) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return