Effect of sequential treatment of progressive ischemic stroke by butylphthalide

  Objective  To observe the effect of sequential butylphthalide therapy on progressive ischemic stroke (PIS).

  Methods  A total of 102 patients with PIS were randomly divided into control group and observation group, with 51 patients in each group. The control group was given basic treatment, and the observation group was given sequential butylphthalide treatment combined with basic treatment. Neurological deficit score (NIHSS), ability of daily living (ADL), plasma 3-mercaptopyruvate sulfurtransferase (3-MST) and β-amyloid peptide 42 (Aβ₄₂) expression levels as well as the incidence of ADR were compared between two groups before and after treatment.

  Results  The NIHSS scores in two groups were significantly lower than before treatment, and observation group was significantly lower than that in the control group (P < 0.05). The ADL scores in two groups were significantly higher than before treatment, and observation group was significantly higher than that in the control group (P < 0.05). The plasma 3-MST level of observation group was significantly higher than that in the control group, and the plasma Aβ₄₂ level of observation group was significantly lower than that in the control group (P < 0.05).

  Conclusion  Sequential treatment with butylphthalide can significantly improve the neurological dysfunction of patients with PIS, improve the ability of daily living, and has good safety.