GAO Nairong, GUO Jingrui. Research on budesonide aerosol inhalation in treatment of children with asthma[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 63-66. DOI: 10.7619/jcmp.202014017
Citation: GAO Nairong, GUO Jingrui. Research on budesonide aerosol inhalation in treatment of children with asthma[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 63-66. DOI: 10.7619/jcmp.202014017

Research on budesonide aerosol inhalation in treatment of children with asthma

More Information
  • Received Date: May 11, 2020
  • Objective To investigate the effects of budesonide aerosol inhalation on immune function and adverse reactions in children with asthma. Methods A simple random sampling method was used to select 100 asthmatic children, and they were divided into two groups according to lottery method. The control group(n=50)received routine treatment, and the study group(n=50)received budesonide atomization inhalation. The levels of inflammation as well as lung function indexes, immune function indexes and adverse reactions were compared between the two groups. Results After treatment, interleukin-4(IL-4)and interleukin-6(IL-6)in the study group were lower than those in the control group, and interferon γ(IFN-γ)was significantly higher that in the control group(P<0.05); forced vital capacity(FVC), forced expiratory volume in 1 second(FEV1), 25% maximum expiratory capacity(MEF25)in the study group were higher than those in the control group(P<0.05); the levels of CD4+ and CD4+/CD8+ in the study group were higher, and level of CD8+ was lower than that in the control group(P<0.05); the incidence of adverse reactions was 4.00% in the study group and 8.00% in the control group, but there was no significant difference(P>0.05). Conclusion Budesonide aerosol inhalation in the treatment of children with asthma can reduce inflammation reaction, improve lung function and immune function, and reduce adverse reactions.
  • 黄晓燕, 陈积雄, 罗海伶, 等. 孟鲁司特钠片联合布地奈德、沙丁胺醇、异丙托溴铵雾化吸入治疗支气管哮喘患儿的临床研究[J]. 解放军预防医学杂志, 2019, 37(8): 125-126

    , 129.
    鞠婧婧, 李亚南, 赵宇蕾, 等. 血浆维生素D水平与儿童哮喘的相关性及布地奈德、异丙托溴铵雾化吸入联合维生素D的治疗效果[J]. 实用心脑肺血管病杂志, 2019, 27(11): 93-97.
    王宽锋, 任华, 王翠翠, 等. 孟鲁司特钠联合布地奈德雾化吸入对咳嗽变异性哮喘患儿肺功能的影响[J]. 实用临床医药杂志, 2019, 23(4): 41-43

    , 46.
    李姗姗. 布地奈德雾化吸入治疗小儿哮喘急性发作的疗效及血清炎性因子水平的变化[J]. 儿科药学杂志, 2019, 25(8): 16-19.
    李丽华, 黄秋芳. 口服匹多莫德联合布地奈德雾化吸入治疗儿童咳嗽变异性哮喘的临床效果[J]. 广西医学, 2018, 40(8): 886-889.
    中华医学会儿科学分会呼吸学组. 儿童支气管哮喘诊断与防治指南(2016年版)[J]. 中华儿科杂志, 2016, 54(3): 167-181.
    张吴越, 顾永春, 汤颖, 等. 甘草酸对支气管哮喘小鼠ERK1/2和p38 MAPK信号通路的影响[J]. 中华医学杂志, 2018, 98(16): 1273-1278.
    尹梅. 大剂量硫酸镁注射液雾化吸入治疗学龄前儿童重症哮喘疗效观察[J]. 陕西医学杂志, 2020, 49(1): 109-111.
    代杰, 赵敏. 孟鲁司特联合雾化吸入布地奈德治疗小儿哮喘急性发作的疗效及对患儿血清炎性因子的影响[J]. 中国医院用药评价与分析, 2019, 19(1): 63-65.
    刘彩霞, 吕小芹, 万丽凤. 空气压缩泵与超声雾化吸入布地奈德联合特布他林治疗儿童咳嗽变异性哮喘临床研究[J]. 海南医学, 2019, 30(12): 1557-1560.
    汪燕, 鲁利群, 黄莉, 等. 匹多莫德联合布地奈德雾化吸入对支气管哮喘患儿IL-4, IFN-γ, 免疫球蛋白及T细胞亚群的影响[J]. 现代生物医学进展, 2017, 17(23): 4541-4544.
    郭梅, 王卫. 布地奈德雾化吸入对小儿哮喘患者外周血炎症因子及肺功能的影响[J]. 河北医学, 2017, 23(7): 1086-1090.
    蔡仪术, 陈简, 陈国春. 脾氨肽联合布地奈德治疗小儿支气管哮喘的疗效及其对血清CD4+、CD8+、IgE水平的影响[J]. 儿科药学杂志, 2018, 24(9): 20-23.
    唐卫珍, 徐红梅, 徐吉成, 等. 孟鲁司特钠联合布地奈德混悬液对咳嗽变异性哮喘患儿呼吸功能及血IgE和EOS的影响分析[J]. 中国医学前沿杂志: 电子版, 2017, 9(12): 134-138.
    孙明令, 宋翊. CD4+T、CD8+T、CD4+/CD8+与慢性乙肝不同中医体质存在相关性[J]. 基因组学与应用生物学, 2018, 37(1): 129-135.
    李进, 方代华. T淋巴细胞亚群与NK细胞在小儿支气管肺炎中的变化及意义[J]. 广西医科大学学报, 2019, 36(5): 785-788.
    缪红, 顾玲琪, 顾谦学. 维生素D辅助布地奈德联合复方异丙托溴铵对哮喘患儿肺功能及免疫功能的影响[J]. 实用临床医药杂志, 2019, 23(19): 57-60.
    杨敏, 李林瑞, 孟燕妮, 等. 布地奈德辅助治疗小儿支气管哮喘对T淋巴细胞亚群及相关细胞因子的影响[J]. 疑难病杂志, 2018, 17(3): 255-258

    , 263.
  • Cited by

    Periodical cited type(10)

    1. 古月. 对比缝合止血电凝止血在卵巢良性肿瘤微创术中的疗效及相关指标. 基层医学论坛. 2024(10): 31-33+36 .
    2. 何英,罗寿召. 双侧卵巢良性肿瘤腹腔镜剥除术后卵巢储备功能与子宫内膜容受性的相关性. 中国计划生育学杂志. 2024(08): 1874-1877 .
    3. 吴圆琼,於军,杜玲. 腹腔镜下卵巢囊肿剥除术中运用缝合止血与电凝止血对卵巢功能的保护作用比较. 浙江创伤外科. 2023(02): 374-377 .
    4. 邱文妍. 缝合止血与双极电凝止血在腹腔镜卵巢囊肿剥除术患者中的应用效果比较. 中国民康医学. 2023(23): 162-164+178 .
    5. 徐晓晶. 腹腔镜手术联合缝合止血和电凝止血治疗卵巢良性肿瘤的效果观察. 吉林医学. 2022(07): 1796-1798 .
    6. 曲长红,李广莹,倪换娟,周维,裴丽鹏. 腹腔镜下治疗黄体破裂出血缝合或双极电凝止血对患者应激激素、卵巢功能及免疫功能影响. 中国计划生育学杂志. 2022(10): 2228-2232 .
    7. 陈燕. 腹腔镜下电凝与缝合止血在卵巢囊肿剔除术中的应用效果对比. 实用妇科内分泌电子杂志. 2022(21): 4-7 .
    8. 王紧. 腹腔镜下卵巢囊肿剥除术后卵巢储备功能下降发生的高危因素. 医药论坛杂志. 2021(14): 64-67 .
    9. 李伟玲,左欣,陈芳,吴海峰,朱红娣. 单孔腹腔镜手术治疗卵巢良性肿瘤的临床效果探讨. 世界复合医学. 2021(09): 145-148 .
    10. 张雯,吴衡慧,杜近云. 腹腔镜与开腹单侧卵巢良性肿物剔除术对卵巢储备功能的影响比较. 河南医学研究. 2021(35): 6581-6584 .

    Other cited types(1)

Catalog

    Article views (382) PDF downloads (14) Cited by(11)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return