Advances in research on the correlation between cadherin 23 and deafness

FENG Shuai; YANG Lihui; LI Weiguang; WANG Zhixiang; HUI Lian

doi:10.7619/jcmp.202013036

Journal of Clinical Medicine in Practice > 2020 > 24(13): 128-132. > DOI: 10.7619/jcmp.202013036

FENG Shuai, YANG Lihui, LI Weiguang, WANG Zhixiang, HUI Lian. Advances in research on the correlation between cadherin 23 and deafness[J]. Journal of Clinical Medicine in Practice, 2020, 24(13): 128-132. DOI: 10.7619/jcmp.202013036

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Advances in research on the correlation between cadherin 23 and deafness

1. Department of Otolaryngology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110000;
2. Department of Otolaryngology, The People's Hospital of Liaoning Province, Shenyang, Liaoning, 110000

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Received Date: April 20, 2020

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Abstract

Abstract

Deafness is one of the common causes of disability. Its occurrence and development are affected by many factors. A large number of basic clinical studies have shown that cadherin 23 is a cellular structural protein closely related to the function of the inner ear. In this study, the molecular structure and biological function of cadherin 23 were reviewed, the role of cadherin 23 in hair cell development and its correlation with clinical symptoms were described, and the important role of cadherin 23 in maintaining the morphological and functional integrity of hair cell bundles in the inner ear was revealed. At the same time, the application of different mutation forms of cadherin 23 gene(Cdh23)encoding cadherin 23 in clinical detection was explored, aiming to provide a new direction for early clinical gene diagnosis research of deafness.
- cadherin 23,
- deafness,
- hair cells,
- noise-induced hearing loss

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References (35)

References

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