Observation on efficacy of 5-aminolevulinic acid photodynamic therapy for low-grade squamous intraepithelial lesion with high-risk human papillomavirus infection

CHENG Lenan; GE Licong; LU Xiaoli; LI Ning; YANG Qiuyun

doi:10.7619/jcmp.20201114

Journal of Clinical Medicine in Practice > 2021 > 25(6): 20-24. > DOI: 10.7619/jcmp.20201114

CHENG Lenan, GE Licong, LU Xiaoli, LI Ning, YANG Qiuyun. Observation on efficacy of 5-aminolevulinic acid photodynamic therapy for low-grade squamous intraepithelial lesion with high-risk human papillomavirus infection[J]. Journal of Clinical Medicine in Practice, 2021, 25(6): 20-24. DOI: 10.7619/jcmp.20201114

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Observation on efficacy of 5-aminolevulinic acid photodynamic therapy for low-grade squamous intraepithelial lesion with high-risk human papillomavirus infection

1.
Department of Gynaecology and Obstetrics, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, 450003
2.
Department of Gynaecology and Obstetrics, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, 450003

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Received Date: October 13, 2020
Available Online: April 08, 2021
Published Date: March 27, 2021

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Abstract

Abstract

Objective To investigate the clinical efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of low-grade cervical squamous intraepithelial lesion (LSIL) patients with high-risk human papillomavirus (HR-HPV) infection.
Methods A total of 60 LSIL patients with HR-HPV infection were divided into control group and observation group according to random number table method, with 30 cases in each group. The control group was treated with routine medicine, while the observation group was treated with ALA-PDT. The treatment effects, the clearance rate of HPV, the scores of Self-rating Anxiety Scale(SAS) and Self-rating Depression Scale (SDS) were compared between the two groups.
Results Six months after treatment, the total effective rate of the observation group was 83.33%, which was significantly higher than 53.33% in the control group(P < 0.05). The clearance rate of HR-HPV in the observation group was significantly higher than that in the control group (P < 0.05). There were no significant differences in SAS and SDS scores between the two groups before treatment(P>0.05). After treatment, SAS and SDS scores in the observation group were significantly lower than those the control group(P < 0.05). No obvious adverse reactions occurred in the two groups.
Conclusion ALA-PDT is a safe and effective method in the treatment of LSIL with HR-HPV infection, and can improve status of anxiety and depression of patients.

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[1]	TSIKOURAS P, ZERVOUDIS S, MANAV B, et al. Cervical cancer: Screening, diagnosis and staging[J]. Journal of Buon, 2016, 21(2): 320-325. http://www.ncbi.nlm.nih.gov/pubmed/27273940
[2]	HELLNER K, DORRELL L. Recent advances in understanding and preventing human papillomavirus-related disease[J]. F1000 Res, 2017, 6: F1000 Faculty Rev-269. doi: 10.12688/f1000research.11587.1
[3]	KURMAN R J, CARCANGIU M L, HERRINGTON C S, et al. WHO classification of tumours of female reproductive organs[M]. 4th Edition. Lyon: IARC, 2014: 172-176, 183-184.
[4]	党敏玲, 王彩娥, 倚西红. 低级别宫颈上皮内病变患者40例治疗及随访[J]. 实用临床医药杂志, 2017, 21(21): 225-227. doi: 10.7619/jcmp.201721094
[5]	李瑞, 刘莉娜, 陈立达. 氨乙酰丙酸介导的光动力疗法对宫颈人乳头瘤病毒感染合并宫颈上皮内瘤变的疗效影响[J]. 实用临床医药杂志, 2019, 23(11): 63-65, 69. doi: 10.7619/jcmp.201911018
[6]	张韶凯, 赵方辉, 乔友林. 中国宫颈癌防治研究20年历程与成就[J]. 中华流行病学杂志, 2020, 41(6): 809-812.
[7]	WANG J, ELFSTRñM K M, Andrae B, et al. Cervical cancer case-control audit: Results from routine evaluation of a nationwide cervical screening program[J]. Int J Cancer, 2020, 146(5): 1230-1240. doi: 10.1002/ijc.32416
[8]	魏丽惠, 沈丹华, 赵方辉, 等. 中国子宫颈癌筛查及异常管理相关问题专家共识(二)[J]. 中国妇产科临床杂志, 2017, 18(3): 286-288. https://www.cnki.com.cn/Article/CJFDTOTAL-FKLC201703043.htm
[9]	李明珠, 赵昀, 李静然, 等. 2019 ASCCP基于风险的子宫颈癌筛查结果异常的管理共识解读[J]. 中国妇产科临床杂志, 2020, 21(4): 446-448. https://www.cnki.com.cn/Article/CJFDTOTAL-FKLC202004036.htm
[10]	丁阳, 卢建军. 宫颈锥切术对妊娠结局影响的研究进展[J]. 中国实用医刊, 2020(15): 119-122. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY201416028.htm
[11]	SOERGEL P, WANG X, STEPP H, et al. Photodynamic therapy of cervical intraepithelial neoplasia with hexaminolevulinate[J]. Lasers Surg Med, 2008, 40(9): 611-615. doi: 10.1002/lsm.20686
[12]	苏小玉, 蒙莉萍, 邹聪聪, 等. 重组人干扰素凝胶联合保妇康栓治疗宫颈高危型HPV感染的临床观察[J]. 中国药房, 2020, 31(8): 984-988. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYA202008016.htm
[13]	徐永娟, 陈昕华, 叶文凤. 冷冻联合重组人干扰素α-2b栓治疗宫颈低级别鳞状上皮内病变的效果探究[J]. 中国继续医学教育, 2017, 9(20): 164-165. https://www.cnki.com.cn/Article/CJFDTOTAL-JXUY201720101.htm
[14]	王燕婷, 陈丽影, 周益美. 加味二妙散联合重组人干扰素α2b治疗低级别宫颈鳞状上皮内病变临床观察[J]. 中外医学研究, 2019, 17(29): 28-30. https://www.cnki.com.cn/Article/CJFDTOTAL-YJZY201929012.htm
[15]	林杏娟, 肖文平, 麦健敏. 重组人干扰素α-2b栓联合物理治疗宫颈上皮内瘤变Ⅰ级合并高危HPV阳性疗效观察[J]. 中国处方药, 2020, 18(2): 108-109. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGCF202002065.htm
[16]	GUO X, QIU L, WANG Y, et al. A randomized open-label clinical trial of an anti-HPV biological dressing(JB01-BD)administered intravaginally to treat high-risk HPV infection[J]. Microbes Infec, 2016, 18(2): 148-152. http://www.sciencedirect.com/science/article/pii/S1286457915002270
[17]	傅裕, 鲍迎秋, 朝鲁, 等. 5-氨基酮戊酸光动力疗法治疗宫颈高危型人乳头瘤病毒感染疗效分析[J]. 临床军医杂志, 2018, 46(7): 752-754. https://www.cnki.com.cn/Article/CJFDTOTAL-JYGZ201807006.htm
[18]	HILLEMANNS P, PETRY K U, SOERGEL P, et al. Efficacy and safety of hexaminolevulinate photodynamic therapy in patients with low-grade cervical intraepithelial neoplasia[J]. Lasers Surg Med, 2014, 46(6): 456-461. doi: 10.1002/lsm.22255
[19]	黄舒婷, 左帆, 刘雯雯, 等. 5-氨基酮戊酸光动力治疗16型或(和)18型人乳头状瘤病毒宫颈持续感染合并宫颈低级别上皮内瘤样病变疗效观察[J]. 妇产与遗传: 电子版, 2020, 10(3): 17-21.

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Observation on efficacy of 5-aminolevulinic acid photodynamic therapy for low-grade squamous intraepithelial lesion with high-risk human papillomavirus infection

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