Effect of glucuronic acid glucosaminoglycan sulfate in intervening diabetic nephropathy

  Objective  To observe effect of glucuronic acid glucosaminoglycan sulfate(sulodexide) in intervening diabetic nephropathy(DN).

  Methods  A total of 40 DN patients were enrolled and randomly divided into observation group(n=20) and control group(n=20). The control group was given routine treatment of diabetes. The observation group was given intramuscular injection of suloxide on this basis of the control group, the patients were treated by 600 LSU per time, once a day, 5 days a week, and 3 weeks as a course of treatment. The second course of treatment was started after 1 week of withdrawal, and the treatment lasted for two weeks. The changes of urinary malondialdehyde, urinary albumin to creatinine (UACR) ratio, urinary transforming growth factor-β₁ (TGF-β₁), serum adiponectin (ADPN), glycated hemoglobin (HbA1c), estimated glomerular filtration rate (eGFR) and fasting blood glucose (FBG) in two groups were compared before treatment and 1 month, 2 and 3 months after treatment.

  Results  There were no significant between-group differences in HbA1c and FBG between two groups before and after treatment(P>0.05). After treatment, the levels of eGFR and serum ADPN in the observation group were significantly higher than those in the control group, while the levels of urinary malondialdehyde, UACR and urinary TGF-β₁ were significantly lower than those in the control group(P < 0.05 or P < 0.01).

  Conclusion  Sulodexide has protective effects on renal vascular function and renal tubular function in DN patients, and may delay the progression of renal damage in early stage.