Research advance on relationship between tetrahydrobiopterin and tumor

Cancer threatens human's life and its incidence is increasing year by year. The pathogenesis of cancer is complex, and its occurrence is the result of multi-factor interaction and multistage process. With the functions of anti-oxidation and removing active nitrogen oxides, tetrahydrobiopterin(BH4)is a coenzyme of aromatic amino acid hydroxylase and nitric oxide synthase, and plays a key role in a series of physiological and pathological process in vivo. Recent studies has shown that BH4 plays a role in the occurrence and development of malignant tumor, and has double functions in promoting and inhibiting the development of tumor.