PU Jinjun, LUO Jiaqi, ZHOU Dandan, MIAO Congliang, FANG Bochu, SUN Yanni. Predictive value of serum proadrenomedullin in acute cerebral infarction patients with stroke-associated pneumonia[J]. Journal of Clinical Medicine in Practice, 2020, 24(5): 47-52. DOI: 10.7619/jcmp.202005013
Citation: PU Jinjun, LUO Jiaqi, ZHOU Dandan, MIAO Congliang, FANG Bochu, SUN Yanni. Predictive value of serum proadrenomedullin in acute cerebral infarction patients with stroke-associated pneumonia[J]. Journal of Clinical Medicine in Practice, 2020, 24(5): 47-52. DOI: 10.7619/jcmp.202005013

Predictive value of serum proadrenomedullin in acute cerebral infarction patients with stroke-associated pneumonia

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  • Received Date: December 07, 2019
  • Available Online: August 26, 2020
  • Objective To investigate the predictive value of serum proadrenomedullin(pro-ADM)level in acute cerebral infarction patients with stroke-associated pneumonia(SAP). Methods A total of 100 patients with acute cerebral infarction were selected and divided into SAP group(n=43)and non-SAP group(n=57)according to the clinical symptoms and microbiological culture results, and the time to diagnosis of SAP was recorded. The levels of serum pro-ADM were measured by ELISA on 1st, 3rd and 5th day after admission. The predictive value of pro-ADM for SAP was assessed by receiver operating characteristic(ROC)curve analysis. The results of patients diagnosed as SAP on the 3rd and 5th day before the assay were not included in the predictive analysis. The pro-ADM levels of patients with NIHSS score≥10 at admission in SAP group and non-SAP group were compared. Multivariable logistic regression was applied to investigate risk factors for the progression of SAP. Results On the 1st, 3rd and 5th day after hospital admission, the pro-ADM levels were(1.74±0.39),(1.44±0.44)and(1.56±0.47)nmol/L respectively in the SAP group, which were significantly - higher than(1.30±0.33),(1.23±0.42)and(1.13±0.39)nmol/L in non-SAP group(P<0.05 or P<0.01). For diagnosis of SAP, the area under the ROC curve( AUC)for pro-ADM on 1st, 3rd and 5th were 0.807(95% CI was 0.724 to 0.890), 0.636(95% CI was 0.521 to 0.751)and 0.760(95% CI was 0.645 to 0.875), respectively. On the 1st and 5th day, the pro-ADM levels of patients with NIHSS score≥10 at admission were(1.71±0.37)and(1.55±0.49)nmol/L in SAP group, which were significantly higher than(1.48±0.34)and(1.24±0.34)nmol/L in non-SAP Group(P<0.05). The multivariable logistic regression analysis showed that a higher NIHSS score and a higher serum pro-ADM level on 1st day after hospital admission were the risk factors for SAP. Conclusion The detection of serum pro-ADM level in the early stage of acute cerebral infarction may be helpful to predict the occurrence of SAP.
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