Objective To investigate the clinical value of fractional exhaled nitric oxide (FeNO) monitoring and detection of alveolar nitric oxide concentration (CANO) in children with asthma.
Methods The clinical data of 79 asthma children with FeNO was retrospectively analyzed. According to the score of childhood asthma control test (C-ACT), all selected cases were divided into mild asthma group (7 cases), moderate asthma group (46 cases) and severe asthma group (26 cases). And 66 healthy children with physical examination were selected as control group. The effects of FeNO monitoring and CANO detection in diagnosis and treatment of children with asthma were analyzed.
Results The levels of FeNO and CANO in severe asthma group were higher than those in moderate asthma group, mild asthma group and control group (P < 0.05); The forced expiratory volume in one second (FEV1%) and peak expiratory flow (PEF%) in severe asthma group were lower than those in moderate asthma group, mild asthma group and control group (P < 0.05). Pearson correlation analysis showed that FENO was negatively correlated with FEV1%(r=-0.239, P < 0.05), and positively correlated with CANO(r=0.511, P < 0.01).
Conclusion FENO and CANO are correlated with pulmonary function, which can be indicators for assessing the condition of children with FENO asthma and guiding the following clinical treatment.
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