Objective To investigate the correlation between resting heart rate (RHR) and serum high-sensitivity C reactive protein (hs-CRP), brain natriuretic peptide (BNP) and left ventricular ejection fraction (LVEF) in patients with chronic heart failure (CHF).
Methods A total of 120 patients with CHF were divided into group A with RHR less than 70 times per minute (n=37), group B with RHR from 70 to 90 times per minute (n=45) and group C with RHR over 90 times per minute (n=38). The levels of hs-CRP, BNP and LVEF were measured and compared among three groups. Pearson method was used to analyze the correlation between RHR and hs-CRP, BNP and LVEF.
Results The proportion of patients with grade Ⅲ to Ⅳ of New York Heart Association (NYHA) in group C was significantly higher than that in group A and group B (P < 0.05). The levels of hs-CRP and BNP in group A, B and C increased in proper order, while LVEF decreased in proper order, and there were significant differences among three groups (P < 0.05). Pearson analysis showed that RHR was positively correlated with hs-CRP and BNP (r=0.493, 0.572, P=0.034, 0.027) and negatively correlated with LVEF (r=-0.518, P=0.031).
Conclusion RHR is positively correlated with hs-CRP, BNP and negatively correlated with LVEF in CHF patients.
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